Animal Models of GWAS-Identified Type 2 Diabetes Genes

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Title: Animal Models of GWAS-Identified Type 2 Diabetes Genes
Author(s): Xavier, GDS
Bellomo, EA
McGinty, JA
French, PM
Rutter, GA
Item Type: Journal Article
Abstract: More than 65 loci, encoding up to 500 different genes, have been implicated by genome-wide association studies (GWAS) as conferring an increased risk of developing type 2 diabetes (T2D). Whilst mouse models have in the past been central to understanding the mechanisms through which more penetrant risk genes for T2D, for example, those responsible for neonatal or maturity-onset diabetes of the young, only a few of those identified by GWAS, notably TCF7L2 and ZnT8/SLC30A8, have to date been examined in mouse models. We discuss here the animal models available for the latter genes and provide perspectives for future, higher throughput approaches towards efficiently mining the information provided by human genetics.
Publication Date: 31-Dec-2013
Date of Acceptance: 18-Mar-2013
URI: http://hdl.handle.net/10044/1/42032
DOI: http://dx.doi.org/10.1155/2013/906590
ISSN: 2314-6753
Publisher: Hindawi Publishing Corporation
Journal / Book Title: Journal of Diabetes Research
Volume: 2013
Copyright Statement: © 2013 Gabriela da Silva Xavier et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
Medicine, Research & Experimental
Research & Experimental Medicine
GENOME-WIDE ASSOCIATION
PANCREATIC BETA-CELL
LIFE-STYLE INTERVENTION
LARGE-SCALE ASSOCIATION
IMPAIRED INSULIN-SECRETION
ZINC TRANSPORTER ZNT8
7-LIKE 2 GENE
GLUCOSE-HOMEOSTASIS
JAPANESE POPULATION
COMMON VARIANTS
Animals
Diabetes Mellitus, Type 2
Disease Models, Animal
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Polymorphism, Single Nucleotide
Animals
Humans
Diabetes Mellitus, Type 2
Disease Models, Animal
Genetic Predisposition to Disease
Polymorphism, Single Nucleotide
Genome-Wide Association Study
Publication Status: Published
Article Number: 906590
Appears in Collections:Physics
Photonics
Department of Medicine
Faculty of Medicine
Faculty of Natural Sciences



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