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The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition

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Title: The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition
Authors: Prosser, G
Brandenburg, J
Reiling, N
Barry III, CE
Wilkinson, RJ
Wilkinson, KA
Item Type: Journal Article
Abstract: M. tuberculosis is a facultative anaerobe and its characteristic pathological hallmark, the granuloma, exhibits hypoxia in humans and in most experimental models. Thus the host and bacillary adaptation to hypoxia is of central importance in understanding pathogenesis and thereby to derive new drug treatments and vaccines.
Issue Date: 22-Oct-2016
Date of Acceptance: 6-Oct-2016
URI: http://hdl.handle.net/10044/1/41901
DOI: https://dx.doi.org/10.1016/j.micinf.2016.10.001
ISSN: 1286-4579
Publisher: Elsevier
Start Page: 177
End Page: 192
Journal / Book Title: Microbes and Infection
Volume: 19
Issue: 3
Copyright Statement: Creative Commons Attribution 4.0 International (CC BY 4.0)
Sponsor/Funder: Wellcome Trust
Funder's Grant Number: 104803/Z/14/ZR
Keywords: Science & Technology
Life Sciences & Biomedicine
Immunology
Infectious Diseases
Microbiology
Tuberculosis
Hypoxia
T cells
Antigens
Macrophage
Lipid droplets
HOST-PATHOGEN INTERACTIONS
ENDOTHELIAL GROWTH-FACTOR
TUMOR-NECROSIS-FACTOR
MYCOBACTERIUM-TUBERCULOSIS
LATENT TUBERCULOSIS
GENE-EXPRESSION
PULMONARY TUBERCULOSIS
IN-VITRO
LIPID-METABOLISM
DOSR REGULON
Animals
Disease Models, Animal
Humans
Macrophages
Mycobacterium tuberculosis
T-Lymphocytes
0605 Microbiology
1107 Immunology
1108 Medical Microbiology
Publication Status: Published
Appears in Collections:Department of Medicine
Faculty of Medicine



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