Ambient air pollution, traffic noise and adult asthma prevalence: a BioSHaRE approach

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Title: Ambient air pollution, traffic noise and adult asthma prevalence: a BioSHaRE approach
Authors: Cai, Y
Zijlema, WL
Doiron, D
Blangiardo, M
Burton, PR
Fortier, I
Gaye, A
Gulliver, J
De Hoogh, K
Hveem, K
Mbatchou, S
Morley, DW
Stolk, RP
Elliott, P
Hansell, AL
Hodgson, S
Item Type: Journal Article
Abstract: We investigated the effects of both ambient air pollution and traffic noise on adult asthma prevalence, using harmonised data from three European cohort studies established in 2006–2013 (HUNT3, Lifelines and UK Biobank).Residential exposures to ambient air pollution (particulate matter with aerodynamic diameter <=10 µm (PM10) and nitrogen dioxide (NO2)) were estimated by a pan-European Land Use Regression model for 2007. Traffic noise for 2009 was modelled at home addresses by adapting a standardised noise assessment framework (CNOSSOS-EU). A cross-sectional analysis of 646 731 participants aged >=20 years was undertaken using DataSHIELD to pool data for individual-level analysis via a “compute to the data” approach. Multivariate logistic regression models were fitted to assess the effects of each exposure on lifetime and current asthma prevalence.PM10 or NO2 higher by 10 µg·m-3 was associated with 12.8% (95% CI 9.5–16.3%) and 1.9% (95% CI 1.1–2.8%) higher lifetime asthma prevalence, respectively, independent of confounders. Effects were larger in those aged >=50 years, ever-smokers and less educated. Noise exposure was not significantly associated with asthma prevalence.This study suggests that long-term ambient PM10 exposure is associated with asthma prevalence in western European adults. Traffic noise is not associated with asthma prevalence, but its potential to impact on asthma exacerbations needs further investigation.Long-term ambient PM10 exposure is associated with asthma prevalence in three European adult cohorts
Issue Date: 20-Oct-2016
Date of Acceptance: 1-Sep-2016
ISSN: 0903-1936
Publisher: European Respiratory Society
Journal / Book Title: European Respiratory Journal
Volume: 49
Issue: 1
Copyright Statement: © ERS 2016
Sponsor/Funder: National Institute for Health Research
Imperial College Healthcare NHS Trust- BRC Funding
Commission of the European Communities
Medical Research Council (MRC)
National Institute for Health Research
Funder's Grant Number: NF-SI-0611-10136
RDC01 79560
Keywords: Respiratory System
11 Medical And Health Sciences
Publication Status: Published
Article Number: 1502127
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care

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