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DROPLAY: laser writing of functional patterns within biological microdroplet displays

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Title: DROPLAY: laser writing of functional patterns within biological microdroplet displays
Authors: Chan, CL
Bolognesi, G
Bhandarkar, A
Friddin, M
Brooks, NJ
Seddon, J
Law, R
Barter, L
Ces
Item Type: Journal Article
Abstract: In this study, we introduce an optofluidic method for the rapid construction of large-area cell-sized droplet assemblies with user-defined re-writable two-dimensional patterns of functional droplets. Light responsive water-in-oil droplets capable of releasing fluorescent dye molecules upon exposure were generated and self-assembled into arrays in a microfluidic device. This biological architecture was exploited by the scanning laser of a confocal microscope to ‘write’ user defined patterns of differentiated (fluorescent) droplets in a network of originally undifferentiated (non-fluorescent) droplets. As a result, long lasting images were produced on a droplet fabric with droplets acting as pixels of a biological monitor, which can be erased and re-written on-demand. Regio-specific light-induced droplet differentiation within a large population of droplets provides a new paradigm for the rapid construction of bio-synthetic systems with potential as tissue mimics and biological display materials.
Issue Date: 18-Oct-2016
Date of Acceptance: 18-Oct-2016
URI: http://hdl.handle.net/10044/1/41815
DOI: https://dx.doi.org/10.1039/C6LC01219A
ISSN: 1473-0197
Publisher: Royal Society of Chemistry
Start Page: 4621
End Page: 4627
Journal / Book Title: Lab on a Chip
Volume: 16
Copyright Statement: © The Royal Society of Chemistry 2016. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (https://creativecommons.org/licenses/by/3.0/)
Sponsor/Funder: Engineering & Physical Science Research Council (EPSRC)
Engineering & Physical Science Research Council (E
Funder's Grant Number: EP/J017566/1
EP/K503733/1
Keywords: Analytical Chemistry
03 Chemical Sciences
09 Engineering
Publication Status: Published
Appears in Collections:Chemistry
Biological and Biophysical Chemistry
Faculty of Natural Sciences



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