Imaging biomarker roadmap for cancer studies

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Title: Imaging biomarker roadmap for cancer studies
Author(s): O'Connor, JP
Aboagye, EO
Adams, JE
Aerts, HJ
Barrington, SF
Beer, AJ
Boellaard, R
Bohndiek, SE
Brady, M
Brown, G
Buckley, DL
Chenevert, TL
Clarke, LP
Collette, S
Cook, GJ
DeSouza, NM
Dickson, JC
Dive, C
Evelhoch, JL
Faivre-Finn, C
Gallagher, FA
Gilbert, FJ
Gillies, RJ
Goh, V
Griffiths, JR
Groves, AM
Halligan, S
Harris, AL
Hawkes, DJ
Hoekstra, OS
Huang, EP
Hutton, BF
Jackson, EF
Jayson, GC
Jones, A
Koh, DM
Lacombe, D
Lambin, P
Lassau, N
Leach, MO
Lee, TY
Leen, EL
Lewis, JS
Liu, Y
Lythgoe, MF
Manoharan, P
Maxwell, RJ
Miles, KA
Morgan, B
Morris, S
Ng, T
Padhani, AR
Parker, GJ
Partridge, M
Pathak, AP
Peet, AC
Punwani, S
Reynolds, AR
Robinson, SP
Shankar, LK
Sharma, RA
Soloviev, D
Stroobants, S
Sullivan, DC
Taylor, SA
Tofts, PS
Tozer, GM
Van Herk, M
Walker-Samuel, S
Wason, J
Williams, KJ
Workman, P
Yankeelov, TE
Brindle, KM
McShane, LM
Jackson, A
Waterton, JC
Item Type: Journal Article
Abstract: Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs used daily in oncology include clinical TNM stage, objective response and left ventricular ejection fraction. Other CT, MRI, PET and ultrasonography biomarkers are used extensively in cancer research and drug development. New IBs need to be established either as useful tools for testing research hypotheses in clinical trials and research studies, or as clinical decision-making tools for use in healthcare, by crossing 'translational gaps' through validation and qualification. Important differences exist between IBs and biospecimen-derived biomarkers and, therefore, the development of IBs requires a tailored 'roadmap'. Recognizing this need, Cancer Research UK (CRUK) and the European Organisation for Research and Treatment of Cancer (EORTC) assembled experts to review, debate and summarize the challenges of IB validation and qualification. This consensus group has produced 14 key recommendations for accelerating the clinical translation of IBs, which highlight the role of parallel (rather than sequential) tracks of technical (assay) validation, biological/clinical validation and assessment of cost-effectiveness; the need for IB standardization and accreditation systems; the need to continually revisit IB precision; an alternative framework for biological/clinical validation of IBs; and the essential requirements for multicentre studies to qualify IBs for clinical use.
Publication Date: 11-Oct-2016
Date of Acceptance: 1-Oct-2016
ISSN: 1759-4782
Publisher: Nature Publishing Group
Start Page: 169
End Page: 186
Journal / Book Title: Nature Reviews Clinical Oncology
Volume: 14
Sponsor/Funder: Medical Research Council (MRC)
Cancer Research UK
Cancer Research UK
Engineering & Physical Science Research Council (EPSRC)
US Army (US)
Cancer Research UK
National Institute for Health Research
Scottish Power Foundation
Pfizer Limited
Commission of the European Communities
Cancer Research UK
Cancer Research UK
Cancer Research UK
Medical Research Council (MRC)
Cancer Research UK
Imperial College Healthcare NHS Trust- BRC Funding
Imperial College Healthcare NHS Trust- BRC Funding
Cancer Research UK
National Institute for Health Research
Imperial College Healthcare NHS Trust- BRC Funding
Imperial College Healthcare NHS Trust- BRC Funding
Imperial College Healthcare NHS Trust- BRC Funding
Medical Research Council (MRC)
Medical Research Council (MRC)
GlaxoSmithKline Services Unlimited
Funder's Grant Number: G0700915
C42671 / A12991
RDC04 79560
RDB01 79560
C42671 / A12993
RDC04 79560
RDC04 79560
RDB03 79560
Mark Buswell
Copyright Statement: © 2016 Macmillan Publishers Limited, part of Springer Nature. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
Publication Status: Published
Appears in Collections:Division of Surgery
Division of Cancer
Department of Medicine
Faculty of Medicine

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