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Rapid, low cost prototyping of transdermal devices for personal healthcare monitoring

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1-s2.0-S2214180416301490-main.pdfAccepted version1.19 MBAdobe PDFView/Open
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Title: Rapid, low cost prototyping of transdermal devices for personal healthcare monitoring
Authors: Sharma, S
Saeed, A
Johnson, C
Gadegaard, N
Cass, AEG
Item Type: Journal Article
Abstract: The next generation of devices for personal healthcare monitoring will comprise molecular sensors to monitor analytes of interest in the skin compartment. Transdermal devices based on microneedles offer an excellent opportunity to explore the dynamics of molecular markers in the interstitial fluid, however good acceptability of these next generation devices will require several technical problems associated with current commercially available wearable sensors to be overcome. These particularly include reliability, comfort and cost. An essential pre-requisite for transdermal molecular sensing devices is that they can be fabricated using scalable technologies which are cost effective. We present here a minimally invasive microneedle array as a continuous monitoring platform technology. Method for scalable fabrication of these structures is presented. The microneedle arrays were characterised mechanically and were shown to penetrate human skin under moderate thumb pressure. They were then functionalised and evaluated as glucose, lactate and theophylline biosensors. The results suggest that this technology can be employed in the measurement of metabolites, therapeutic drugs and biomarkers and could have an important role to play in the management of chronic diseases.
Issue Date: 13-Oct-2016
Date of Acceptance: 13-Oct-2016
URI: http://hdl.handle.net/10044/1/41656
DOI: https://dx.doi.org/10.1016/j.sbsr.2016.10.004
ISSN: 2214-1804
Publisher: Elsevier
Start Page: 104
End Page: 108
Journal / Book Title: Sensing and Bio-Sensing Research
Volume: 13
Copyright Statement: Creative Commons Attribution-Non Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0)
Sponsor/Funder: Medical Research Council (MRC)
National Institute for Health Research
Funder's Grant Number: MC_PC_13064
II-LA-0313-20004
Keywords: Continuous glucose monitoring (CGM)
Continuous lactate monitoring (CLM)
Interstitial therapeutic drug monitoring (iTDM)
Microneedles
Minimally invasive sensors
Publication Status: Published
Open Access location: http://authors.elsevier.com/sd/article/S2214180416301490
Appears in Collections:Chemistry
Biological and Biophysical Chemistry
Faculty of Natural Sciences



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