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Mathematical Modelling to Guide Drug Development for Malaria Elimination

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Title: Mathematical Modelling to Guide Drug Development for Malaria Elimination
Authors: Slater, HC
Okell, LC
Ghani, AC
Item Type: Journal Article
Abstract: Mathematical models of the dynamics of a drug within the host are now frequently used to guide drug development. These generally focus on assessing the efficacy and duration of response to guide patient therapy. Increasingly, antimalarial drugs are used at the population level, to clear infections, provide chemoprevention, and to reduce onward transmission of infection. However, there is less clarity on the extent to which different drug properties are important for these different uses. In addition, the emergence of drug resistance poses new threats to longer-term use and highlights the need for rational drug development. Here, we argue that integrating within-host pharmacokinetic and pharmacodynamic (PK/PD) models with mathematical models for the population-level transmission of malaria is key to guiding optimal drug design to aid malaria elimination.
Issue Date: 7-Oct-2016
Date of Acceptance: 1-Oct-2016
URI: http://hdl.handle.net/10044/1/41556
DOI: https://dx.doi.org/10.1016/j.pt.2016.09.004
ISSN: 1471-5007
Publisher: Elsevier
Start Page: 175
End Page: 184
Journal / Book Title: Trends in Parasitology
Volume: 33
Issue: 3
Copyright Statement: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Sponsor/Funder: Medical Research Council (MRC)
Medical Research Council (MRC)
Medicines for Malaria Venture
The Royal Society
Funder's Grant Number: G1002387
MR/K010174/1B
PO14/00561
DH140134
Keywords: Science & Technology
Life Sciences & Biomedicine
Parasitology
PLASMODIUM-FALCIPARUM MALARIA
ARTEMISININ COMBINATION THERAPIES
SUB-SAHARAN AFRICA
PHARMACOKINETIC-PHARMACODYNAMIC MODELS
ANTIMALARIAL-DRUGS
ARTEMETHER-LUMEFANTRINE
OPERATIONAL STRATEGIES
MULTIDRUG-RESISTANCE
GAMETOCYTE CARRIAGE
POTENTIAL IMPACT
Plasmodium falciparum
Plasmodium vivax
drug development
drug-based strategies
malaria
mathematical modelling
Antimalarials
Disease Eradication
Drug Design
Drug Resistance
Humans
Malaria, Falciparum
Models, Theoretical
06 Biological Sciences
07 Agricultural And Veterinary Sciences
11 Medical And Health Sciences
Mycology & Parasitology
Publication Status: Published
Open Access location: http://authors.elsevier.com/sd/article/S147149221630160X
Appears in Collections:Centre for Environmental Policy
Faculty of Medicine
Faculty of Natural Sciences
Epidemiology, Public Health and Primary Care



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