Vitamin D modulation of innate immune responses to respiratory viral infections

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Title: Vitamin D modulation of innate immune responses to respiratory viral infections
Author(s): Zdrenghea, MT
Makrinioti, H
Bagacean, C
Bush, A
Johnston, SL
Stanciu, LA
Item Type: Journal Article
Abstract: Vitamin D, in addition to its classical functions in bone homeostasis, has a modulatory and regulatory role in multiple processes, including host defense, inflammation, immunity, and epithelial repair. Patients with respiratory disease are frequently deficient in vitamin D, implying that supplementation might provide significant benefit to these patients. Respiratory viral infections are common and are the main trigger of acute exacerbations and hospitalization in children and adults with asthma and other airways diseases. Respiratory monocytes/macrophages and epithelial cells constitutively express the vitamin D receptor. Vitamin D, acting through this receptor, may be important in protection against respiratory infections. Whether the in vitro findings can be translated into a substantial in vivo benefit still remains uncertain. Here we review the in vitro data on the role of vitamin D in antiviral innate immunity, the data concerning the deficient levels of vitamin D in lung diseases, and the in vivo role of supplementation as protection against respiratory viral infections in healthy individuals and in patients with chronic respiratory diseases. Finally, we suggest ways of improving the effectiveness of vitamin D as an adjuvant in the prevention and treatment of acute respiratory infections.
Publication Date: 7-Oct-2016
Date of Acceptance: 30-Aug-2016
URI: http://hdl.handle.net/10044/1/41529
DOI: https://dx.doi.org/10.1002/rmv.1909
ISSN: 1099-1654
Publisher: Wiley
Journal / Book Title: Reviews in Medical Virology
Volume: 27
Issue: 1
Copyright Statement: © 2016 John Wiley & Sons, Ltd. This is the accepted version of the following article: Zdrenghea, M. T., Makrinioti, H., Bagacean, C., Bush, A., Johnston, S. L., and Stanciu, L. A. (2016) Vitamin D modulation of innate immune responses to respiratory viral infections. Rev. Med. Virol., which has been published in final form at http://dx.doi.org/10.1002/rmv.1909.
Sponsor/Funder: Commission of the European Communities
Medical Research Council (MRC)
British Medical Association
Funder's Grant Number: 233015
G1000758
BMA Research Grants 2013
Keywords: innate immunity
respiratory viruses
vitamin D
Virology
1108 Medical Microbiology
Publication Status: Published
Article Number: e1909
Appears in Collections:National Heart and Lung Institute
Faculty of Medicine



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