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Prediagnostic selenium status and hepatobiliary cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.

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Title: Prediagnostic selenium status and hepatobiliary cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.
Authors: Hughes, DJ
Duarte-Salles, T
Hybsier, S
Trichopoulou, A
Stepien, M
Aleksandrova, K
Overvad, K
Tjønneland, A
Olsen, A
Affret, A
Fagherazzi, G
Boutron-Ruault, MC
Katzke, V
Kaaks, R
Boeing, H
Bamia, C
Lagiou, P
Peppa, E
Palli, D
Krogh, V
Panico, S
Tumino, R
Sacerdote, C
Bueno-de-Mesquita, HB
Peeters, PH
Engeset, D
Weiderpass, E
Lasheras, C
Agudo, A
Sánchez, MJ
Navarro, C
Ardanaz, E
Dorronsoro, M
Hemmingsson, O
Wareham, NJ
Khaw, KT
Bradbury, KE
Cross, AJ
Gunter, M
Riboli, E
Romieu, I
Schomburg, L
Jenab, M
Item Type: Journal Article
Abstract: BACKGROUND: Selenium status is suboptimal in many Europeans and may be a risk factor for the development of various cancers, including those of the liver and biliary tract. OBJECTIVE: We wished to examine whether selenium status in advance of cancer onset is associated with hepatobiliary cancers in the EPIC (European Prospective Investigation into Cancer and Nutrition) study. DESIGN: We assessed prediagnostic selenium status by measuring serum concentrations of selenium and selenoprotein P (SePP; the major circulating selenium transfer protein) and examined the association with hepatocellular carcinoma (HCC; n = 121), gallbladder and biliary tract cancers (GBTCs; n = 100), and intrahepatic bile duct cancer (IHBC; n = 40) risk in a nested case-control design within the EPIC study. Selenium was measured by total reflection X-ray fluorescence, and SePP was determined by a colorimetric sandwich ELISA. Multivariable ORs and 95% CIs were calculated by using conditional logistic regression. RESULTS: HCC and GBTC cases, but not IHBC cases, showed significantly lower circulating selenium and SePP concentrations than their matched controls. Higher circulating selenium was associated with a significantly lower HCC risk (OR per 20-μg/L increase: 0.41; 95% CI: 0.23, 0.72) but not with the risk of GBTC or IHBC. Similarly, higher SePP concentrations were associated with lowered HCC risk only in both the categorical and continuous analyses (HCC: P-trend ≤ 0.0001; OR per 1.5-mg/L increase: 0.37; 95% CI: 0.21, 0.63). CONCLUSION: These findings from a large prospective cohort provide evidence that suboptimal selenium status in Europeans may be associated with an appreciably increased risk of HCC development.
Issue Date: 29-Jun-2016
Date of Acceptance: 29-Apr-2016
URI: http://hdl.handle.net/10044/1/41486
DOI: https://dx.doi.org/10.3945/ajcn.116.131672
ISSN: 1938-3207
Publisher: American Society for Nutrition
Start Page: 406
End Page: 414
Journal / Book Title: American Journal of Clinical Nutrition
Volume: 104
Issue: 2
Copyright Statement: This is a closed deposit for REF purposes only. This article will not be made publicly available.
Sponsor/Funder: University Medical Center Utrecht
Imperial College Trust
Funder's Grant Number: N/A
P47328
Keywords: Science & Technology
Life Sciences & Biomedicine
Nutrition & Dietetics
hepatocellular carcinoma
selenium
selenoprotein P
prospective cohort
liver cancer
hepatobiliary cancer
selenium status
HEPATOCELLULAR-CARCINOMA
SELENOPROTEIN-P
PLASMA SELENIUM
CHRONIC HEPATITIS
LIVER-CIRRHOSIS
BILIARY-TRACT
DISEASE
EXPRESSION
BIOMARKERS
VIRUS
11 Medical And Health Sciences
09 Engineering
Publication Status: Published
Embargo Date: publication subject to indefinite embargo
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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