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The vaginal microbiota, human papillomavirus infection and cervical intraepithelial neoplasia: what do we know and where are we going next?

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Title: The vaginal microbiota, human papillomavirus infection and cervical intraepithelial neoplasia: what do we know and where are we going next?
Authors: Mitra, A
Macintyre, DA
Marchesi
Lee, YS
Bennett, PR
Kyrgiou, M
Item Type: Journal Article
Abstract: The vaginal microbiota plays a significant role in health and disease of the female reproductive tract. Next-generation sequencing techniques based upon analysis of bacterial 16S rRNA genes permits in-depth study of vaginal microbial community structure to a level of detail not possible with standard culture based microbiological techniques. The Human Papillomavirus (HPV) causes both cervical intraepithelial neoplasia (CIN) and cervical cancer. Although the virus is highly prevalent, only a small number of women have a persistent HPV infection and subsequently develop clinically significant disease. There is emerging evidence which leads us to conclude that increased diversity of vaginal microbiota combined with reduced relative abundance of Lactobacillus spp. is involved in HPV acquisition and persistence, and the development of cervical precancer and cancer. In this review we summarise the current literature, and discuss potential mechanisms for the involvement of vaginal microbiota in the evolution of CIN and cervical cancer. The concept of manipulation of vaginal bacterial communities using pre- and probiotics is also discussed as an exciting prospect for the field of cervical pathology.
Issue Date: 1-Nov-2016
Date of Acceptance: 10-Oct-2016
URI: http://hdl.handle.net/10044/1/41458
DOI: http://dx.doi.org/10.1186/s40168-016-0203-0
ISSN: 2049-2618
Publisher: BioMed Central
Journal / Book Title: Microbiome
Volume: 4
Copyright Statement: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Sponsor/Funder: Imperial College Healthcare NHS Trust- BRC Funding
British Society for Colposcopy and Cervical Pathology
Imperial College Healthcare Charity
Medical Research Council (MRC)
Medical Research Council (MRC)
Genesis Research Trust
Imperial College Healthcare Charity
Imperial College Healthcare NHS Trust- BRC Funding
Funder's Grant Number: RDD03 79560
N/A
7114/R17R
MR/L009226/1
MR/L009226/1
01020
RDD03 79560
Keywords: CIN
Cervical cancer
Cervical intraepithelial neoplasia
HPV
Human papillomavirus
Lactobacillus species
Prebiotics
Probiotics
Vaginal microbiota
Publication Status: Published
Article Number: 58
Appears in Collections:Division of Surgery
Faculty of Medicine



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