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Metabolic phenotyping for discovery of urinary biomarkers of diet, xenobiotics and blood pressure in the INTERMAP Study: An overview

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Title: Metabolic phenotyping for discovery of urinary biomarkers of diet, xenobiotics and blood pressure in the INTERMAP Study: An overview
Authors: Chan, Q
Loo, RL
Ebbels, TMD
Van Horn, L
Daviglus, ML
Stamler, J
Nicholson, JK
Holmes, E
Elliott, P
Item Type: Journal Article
Abstract: The aetiopathogenesis of cardiovascular diseases (CVD) is multifactorial. Adverse blood pressure (BP) is a major independent risk factor for epidemic CVD affecting about 40% of the adult population worldwide and resulting in significant morbidity and mortality. Metabolic phenotyping of biological fluids has proven its application in characterisin g low molecule weight metabolites providing novel insights into gene -environmental -gut microbiome interaction in relations to a disease state. In this review, we synthesi s e key results from the International Study of Macro/Micronutrients and Blood Pressure (INTERMAP) Study, a cross - sectional epidemiological study of 4,680 men and women aged 40 -59 years from Japan, the People’s Republic of China, the United Kingdom, and the United States. We describe the advancements we have made on: 1) analytical techniques for high throughput metabolic phenotyping; 2) statistical analyses for biomarker identification; 3) discovery of unique food - specific biomarkers; and 4) application of metabolome -wide association (MWA) studies to gain a better understanding into the molecular mechanisms of cross cultural and regional BP differences.
Issue Date: 22-Dec-2016
Date of Acceptance: 7-Oct-2016
URI: http://hdl.handle.net/10044/1/41287
DOI: https://dx.doi.org/10.1038/hr.2016.164
ISSN: 1348-4214
Publisher: Nature Publishing Group
Start Page: 336
End Page: 345
Journal / Book Title: Hypertension Research
Volume: 40
Copyright Statement: Copyright © 2016, Rights Managed by Nature Publishing Group
Sponsor/Funder: National Institutes of Health
National Institute for Health Research
Imperial College Healthcare NHS Trust- BRC Funding
National Institutes of Health
Medical Research Council (MRC)
Funder's Grant Number: 0600 370 D330 1362
NF-SI-0611-10136
RDC01 79560
60024563 ICL
MC_PC_12025
Keywords: Science & Technology
Life Sciences & Biomedicine
Peripheral Vascular Disease
Cardiovascular System & Cardiology
blood pressure
metabolic phenotyping
metabonomics
molecular epidemiology
OPTIMIZED STATISTICAL APPROACH
SYMPATHETIC-NERVOUS-SYSTEM
CHRONIC KIDNEY-DISEASE
REPUBLIC-OF-CHINA
MAGNETIC-RESONANCE
WIDE ASSOCIATION
RISK-FACTORS
H-1-NMR SPECTROSCOPY
NMR-SPECTROSCOPY
GUT MICROBIOTA
1103 Clinical Sciences
1102 Cardiovascular Medicine And Haematology
Cardiovascular System & Hematology
Publication Status: Published
Appears in Collections:Division of Surgery
Faculty of Medicine
Epidemiology, Public Health and Primary Care



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