A novel role for GSK3β as a modulator of Drosha microprocessor activity and MicroRNA biogenesis

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Title: A novel role for GSK3β as a modulator of Drosha microprocessor activity and MicroRNA biogenesis
Author(s): Bevan, CL
Fletcher, CE
Godfrey, JD
Shibakawa, A
Bushell, M
Item Type: Journal Article
Abstract: Regulation of microRNA (miR) biogenesis is complex and stringently controlled. Here, we identify the kinase GSK3ß as a important modulator of miR biogenesis at Microprocessor level. Repression of GSK3ß activity reduces Drosha activity towards pri-miRs, leading to accumulation of unprocessed pri-miRs and reduction of mature pri-miRs without altering levels or cellular locations of miR biogenesis proteins...
Publication Date: 23-Oct-2016
Date of Acceptance: 19-Oct-2016
URI: http://hdl.handle.net/10044/1/41279
DOI: https://dx.doi.org/10.1093/nar/gkw938
ISSN: 2159-3345
Publisher: Oxford University Press
Start Page: 2809
End Page: 2828
Journal / Book Title: Nucleic Acid Research
Volume: 45
Issue: 5
Copyright Statement: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: Cancer Research UK
Wellcome Trust
Rosetrees Trust
Prostate Cancer UK
Prostate Cancer Foundation
Funder's Grant Number: 12196
097816/Z/11/A
N/A
DCSJDBAAJ
20160119
Keywords: Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
GLYCOGEN-SYNTHASE KINASE-3
PROSTATE-CANCER
NUCLEAR-LOCALIZATION
IN-VITRO
CELLS
PHOSPHORYLATION
INHIBITION
3-BETA
PROLIFERATION
ACTIVATION
05 Environmental Sciences
06 Biological Sciences
08 Information And Computing Sciences
Developmental Biology
Publication Status: Published
Appears in Collections:Division of Surgery
Division of Cancer
Faculty of Medicine



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