A novel role for GSK3β as a modulator of Drosha microprocessor activity and MicroRNA biogenesis
| File | Description | Size | Format | |
|---|---|---|---|---|
 Nucl. Acids Res.-2016-Fletcher-nar-gkw938.pdf | Published version | 2.94 MB | Adobe PDF | Download |
| FletcherNARAccepted.pdf | Accepted version | 7.74 MB | Adobe PDF | Download |
| Title: | A novel role for GSK3β as a modulator of Drosha microprocessor activity and MicroRNA biogenesis |
| Author(s): | Bevan, CL Fletcher, CE Godfrey, JD Shibakawa, A Bushell, M |
| Item Type: | Journal Article |
| Abstract: | Regulation of microRNA (miR) biogenesis is complex and stringently controlled. Here, we identify the kinase GSK3ß as a important modulator of miR biogenesis at Microprocessor level. Repression of GSK3ß activity reduces Drosha activity towards pri-miRs, leading to accumulation of unprocessed pri-miRs and reduction of mature pri-miRs without altering levels or cellular locations of miR biogenesis proteins... |
| Publication Date: | 23-Oct-2016 |
| Date of Acceptance: | 19-Oct-2016 |
| URI: | http://hdl.handle.net/10044/1/41279 |
| DOI: | https://dx.doi.org/10.1093/nar/gkw938 |
| ISSN: | 2159-3345 |
| Publisher: | Oxford University Press |
| Start Page: | 2809 |
| End Page: | 2828 |
| Journal / Book Title: | Nucleic Acid Research |
| Volume: | 45 |
| Issue: | 5 |
| Sponsor/Funder: | Cancer Research UK Wellcome Trust Rosetrees Trust Prostate Cancer UK Prostate Cancer Foundation |
| Funder's Grant Number: | 12196 097816/Z/11/A N/A DCSJDBAAJ 20160119 |
| Copyright Statement: | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Science & Technology Life Sciences & Biomedicine Biochemistry & Molecular Biology GLYCOGEN-SYNTHASE KINASE-3 PROSTATE-CANCER NUCLEAR-LOCALIZATION IN-VITRO CELLS PHOSPHORYLATION INHIBITION 3-BETA PROLIFERATION ACTIVATION 05 Environmental Sciences 06 Biological Sciences 08 Information And Computing Sciences Developmental Biology |
| Publication Status: | Published |
| Appears in Collections: | Division of Surgery Division of Cancer Faculty of Medicine |
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