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Reducing prostaglandin E2 production to raise cancer immunogenicity

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Title: Reducing prostaglandin E2 production to raise cancer immunogenicity
Authors: Zelenay, S
Reis E Sousa, C
Item Type: Journal Article
Abstract: Cyclooxygenases (COX), commonly upregulated in numerous cancers, generate prostaglandin E2 (PGE2), which has been implicated in key aspects of malignant growth including proliferation, invasion and angiogenesis. Recently, we showed that production of PGE2 by cancer cells dominantly enables progressive tumor growth via immune escape and that cyclooxygenase inhibitors synergize with immunotherapy to enhance tumor eradication.
Issue Date: 4-Jan-2016
Date of Acceptance: 17-Nov-2015
URI: http://hdl.handle.net/10044/1/41236
DOI: http://dx.doi.org/10.1080/2162402X.2015.1123370
ISSN: 2162-4011
Publisher: Taylor & Francis
Journal / Book Title: Oncoimmunology
Volume: 5
Issue: 5
Copyright Statement: This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
Keywords: COX-2
Cancer inflammation
cancer immune evasion
cancer immunity
dendritic cells
immunotherapy
Publication Status: Published
Article Number: e1123370
Appears in Collections:Department of Medicine
Faculty of Medicine



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