Altmetric

The La-Related Proteins, a Family with Connections to Cancer

File Description SizeFormat 
The La-Related Proteins, a Family with Connections to Cancer.pdfPublished version528.01 kBAdobe PDFView/Open
Title: The La-Related Proteins, a Family with Connections to Cancer
Authors: Stavraka, C
Blagden, S
Item Type: Journal Article
Abstract: The evolutionarily-conserved La-related protein (LARP) family currently comprises Genuine La, LARP1, LARP1b, LARP4, LARP4b, LARP6 and LARP7. Emerging evidence suggests each LARP has a distinct role in transcription and/or mRNA translation that is attributable to subtle sequence variations within their La modules and specific C-terminal domains. As emerging research uncovers the function of each LARP, it is evident that La, LARP1, LARP6, LARP7 and possibly LARP4a and 4b are dysregulated in cancer. Of these, LARP1 is the first to be demonstrated to drive oncogenesis. Here, we review the role of each LARP and the evidence linking it to malignancy. We discuss a future strategy of targeting members of this protein family as cancer therapy.
Issue Date: 16-Oct-2015
Date of Acceptance: 7-Oct-2015
URI: http://hdl.handle.net/10044/1/41149
DOI: http://dx.doi.org/10.3390/biom5042701
ISSN: 2218-273X
Publisher: MDPI
Start Page: 2701
End Page: 2722
Journal / Book Title: Biomolecules
Volume: 5
Issue: 4
Copyright Statement: This is an open access article distributed under the Creative Commons Attribution License (CC BY 4.0).
Keywords: LARP
LARP1
RBP
RNA-binding
SS-B
cancer
mRNA
proliferation
transcription
translation
Animals
Autoantigens
Gene Expression Regulation, Neoplastic
Humans
Multigene Family
Neoplasms
Ribonucleoproteins
Publication Status: Published
Appears in Collections:Division of Surgery
Division of Cancer
Faculty of Medicine



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Creative Commonsx