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Systematic Review of Clinical Prediction Scores for Deep Vein Thrombosis

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Title: Systematic Review of Clinical Prediction Scores for Deep Vein Thrombosis
Authors: Kafeza, M
Shalhoub, J
Salooja, N
Bingham, L
Spagou, K
Davies, AH
Item Type: Journal Article
Abstract: Objective: Diagnosis of Deep Vein Thrombosis (DVT) remains a challenging problem. Various clinical prediction rules have been developed in order to improve diagnosis and decision-making in relation to DVT. The purpose of this review is to summarise the available clinical scores and describe their applicability and limitations. Methods: A systematic search of PubMed, MEDLINE and EMBASE databases was conducted in accordance with PRISMA guidance using the keywords: clinical score, clinical prediction rule, risk assessment, clinical probability, pretest probability, diagnostic score and MeSH terms: “Venous Thromboembolism/diagnosis” OR “Venous Thrombosis/diagnosis”. Both development and validation studies were eligible for inclusion. Results: The search strategy returned a total of 2036 articles, of which 102 articles met a priori criteria for inclusion. Eight different diagnostic scores were identified. The development of these scores differs in respect of the population included (hospital inpatients, hospital outpatients or primary care patients), the exclusion criteria, the inclusion of distal DVT and the use of D-dimer. The reliability and applicability of the scores in the context of specific subgroups (inpatients, cancer patients, elderly patients, and those with recurrent DVT) remains controversial. Conclusion: Detailed knowledge of the development of the various clinical prediction scores for DVT is essential in understanding the power, generalisability and limitations of these clinical tools.
Issue Date: 1-Sep-2017
Date of Acceptance: 4-Oct-2016
URI: http://hdl.handle.net/10044/1/41102
DOI: https://dx.doi.org/10.1177/0268355516678729
ISSN: 0268-3555
Publisher: SAGE Publications
Start Page: 516
End Page: 531
Journal / Book Title: Phlebology
Volume: 32
Issue: 8
Copyright Statement: © Sage 2017. The final publication is available via Sage at http://dx.doi.org/10.1177/0268355516678729
Keywords: Science & Technology
Life Sciences & Biomedicine
Surgery
Peripheral Vascular Disease
Cardiovascular System & Cardiology
Deep vein thrombosis
clinical scores
clinical prediction rule
pretest probability
D-DIMER ASSAY
ACUTE VENOUS THROMBOSIS
PRIMARY-CARE PATIENTS
PRETEST PROBABILITY
EMERGENCY-DEPARTMENT
DIAGNOSTIC-VALUE
CANCER-PATIENTS
WELLS-SCORE
SYMPTOMATIC OUTPATIENTS
HOSPITALIZED-PATIENTS
1102 Cardiovascular Medicine And Haematology
Cardiovascular System & Hematology
Publication Status: Published
Appears in Collections:Division of Surgery
Department of Medicine
Faculty of Medicine



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