Differences in antigen-specific CD4+ responses to opportunistic infections in HIV infection

Title: Differences in antigen-specific CD4+ responses to opportunistic infections in HIV infection
Authors: Pollock, KM
Montamat-Sicotte, DJ
Cooke, GS
Kapembwa, MS
Kon, OM
Grass, L
Sampson, RD
Taylor, GP
Lalvani, A
Item Type: Journal Article
Abstract: HIV-infected individuals with severe immunodeficiency are at risk of opportunistic infection (OI). Tuberculosis (TB) may occur without substantial immune suppression suggesting an early and sustained adverse impact of HIV on Mycobacterium tuberculosis (MTB)-specific cell mediated immunity (CMI). This prospective observational cohort study aimed to observe differences in OI-specific and MTB-specific CMI that might underlie this. Using polychromatic flow cytometry, we compared CD4+ responses to MTB, cytomegalovirus (CMV), Epstein-Barr virus (EBV) and Candida albicans in individuals with and without HIV infection. MTB-specific CD4+ T-cells were more polyfunctional than virus specific (CMV/EBV) CD4+ T-cells which predominantly secreted IFN-gamma (IFN-γ) only. There was a reduced frequency of IFN-γ and IL-2 (IL-2)-dual-MTB-specific cells in HIV-infected individuals, which was not apparent for the other pathogens. MTB-specific cells were less differentiated especially compared with CMV-specific cells. CD127 expression was relatively less frequent on MTB-specific cells in HIV co-infection. MTB-specific CD4+ T-cells PD-1 expression was infrequent in contrast to EBV-specific CD4+ T-cells. The variation in the inherent quality of these CD4+ T-cell responses and impact of HIV co-infection may contribute to the timing of co-infectious diseases in HIV infection.
Issue Date: 29-Apr-2015
Date of Acceptance: 28-Jan-2015
URI: http://hdl.handle.net/10044/1/41030
DOI: http://dx.doi.org/10.1002/iid3.50
ISSN: 2050-4527
Publisher: Wiley
Start Page: 141
End Page: 153
Journal / Book Title: Immunity, Inflammation and Disease
Volume: 3
Issue: 3
Copyright Statement: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: British Lung Foundation
Funder's Grant Number: TB08/2
Keywords: Candida albicans
Epstein-Barr virus
HIV
Mycobacterium tuberculosis
cytomegalovirus
Publication Status: Published
Appears in Collections:National Heart and Lung Institute
Department of Medicine
Faculty of Medicine



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