45S5 bioactive glass-based scaffolds coated with cellulose nanowhiskers for bone tissue engineering

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Title: 45S5 bioactive glass-based scaffolds coated with cellulose nanowhiskers for bone tissue engineering
Author(s): Li, W
Garmendia, N
De Larraya, UP
Ding, Y
Detsch, R
Grünewald, A
Roether, JA
Schubert, DW
Boccaccini, AR
Item Type: Journal Article
Abstract: Highly porous 45S5 bioactive glass-based scaffolds prepared by foam replication method were coated with cellulose nanowhiskers by dip coating method. The obtained cellulose nanowhisker-coated scaffolds retained the high porosity and interconnected pore structure. The cellulose coating improved the mechanical properties of the scaffolds and did not hinder their bioactivity in simulated body fluid. In vitro biocompatibility assessment was carried out by qualitative evaluation of the morphology of osteoblast-like cells (MG-63) seeded onto the scaffolds. The cells were shown to attach and spread on both uncoated scaffolds and cellulose nanowhisker-coated scaffolds, thus cellulose nanowhisker coating seems to have no negative influence on the behavior of MG-63 cells. The obtained bioactive and biocompatible composite scaffolds represent promising candidates for bone tissue engineering applications.
Publication Date: 10-Oct-2014
Date of Acceptance: 10-Oct-2014
URI: http://hdl.handle.net/10044/1/41022
DOI: http://dx.doi.org/10.1039/c4ra07740g
ISSN: 2046-2069
Publisher: Royal Society of Chemistry
Start Page: 56156
End Page: 56164
Journal / Book Title: RSC Advances
Volume: 4
Issue: 99
Copyright Statement: This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Publication Status: Published
Appears in Collections:Faculty of Engineering

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