Baseline and lifetime alcohol consumption and risk of differentiated thyroid carcinoma in the EPIC study

Title: Baseline and lifetime alcohol consumption and risk of differentiated thyroid carcinoma in the EPIC study
Authors: Sen, A
Tsilidis, KK
Allen, NE
Rinaldi, S
Appleby, PN
Almquist, M
Schmidt, JA
Dahm, CC
Overvad, K
Tjonneland, A
Rostgaard-Hansen, AL
Clavel-Chapelon, F
Baglietto, L
Boutron-Ruault, M-C
Kuehn, T
Katze, VA
Boeing, H
Trichopoulou, A
Tsironis, C
Lagiou, P
Palli, D
Pala, V
Panico, S
Tumino, R
Vineis, P
Bueno-de-Mesquita, HBA
Peeters, PH
Hjartaker, A
Lund, E
Weiderpass, E
Ramon Quiros, J
Agudo, A
Sanchez, M-J
Arriola, L
Gavrila, D
Barricarte Gurrea, A
Tosovic, A
Hennings, J
Sandstrom, M
Romieu, I
Ferrari, P
Zamora-Ros, R
Khaw, K-T
Wareham, NJ
Riboli, E
Gunter, M
Franceschi, S
Item Type: Journal Article
Abstract: background: Results from several cohort and case–control studies suggest a protective association between current alcohol intake and risk of thyroid carcinoma, but the epidemiological evidence is not completely consistent and several questions remain unanswered. methods: The association between alcohol consumption at recruitment and over the lifetime and risk of differentiated thyroid carcinoma was examined in the European Prospective Investigation into Cancer and Nutrition. Among 477 263 eligible participants (70% women), 556 (90% women) were diagnosed with differentiated thyroid carcinoma over a mean follow-up of 11 years. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using multivariable Cox proportional hazards models. results: Compared with participants consuming 0.1–4.9 g of alcohol per day at recruitment, participants consuming 15 or more grams (approximately 1–1.5 drinks) had a 23% lower risk of differentiated thyroid carcinoma (HR=0.77; 95% CI=0.60–0.98). These findings did not differ greatly when analyses were conducted for lifetime alcohol consumption, although the risk estimates were attenuated and not statistically significant anymore. Similar results were observed by type of alcoholic beverage, by differentiated thyroid carcinoma histology or according to age, sex, smoking status, body mass index and diabetes. conclusions: Our study provides some support to the hypothesis that moderate alcohol consumption may be associated with a lower risk of papillary and follicular thyroid carcinomas.
Issue Date: 27-Aug-2015
Date of Acceptance: 2-Jul-2015
ISSN: 1532-1827
Publisher: Cancer Research UK
Start Page: 840
End Page: 847
Journal / Book Title: British Journal of Cancer
Volume: 113
Issue: 5
Copyright Statement: © 2015 Cancer Research UK. All rights reserved.
Keywords: Science & Technology
Life Sciences & Biomedicine
Alcohol consumption
Thyroid carcinoma
Prospective study
Lifetime exposure
Pooled analysis
Cancer incidence
United States
Alcohol Drinking
Middle Aged
Proportional Hazards Models
Risk Factors
Sex Distribution
Thyroid Neoplasms
Oncology & Carcinogenesis
Publication Status: Published
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care

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