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Common variants at 19p13 are associated with susceptibility to ovarian cancer

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Title: Common variants at 19p13 are associated with susceptibility to ovarian cancer
Authors: Bolton, KL
Tyrer, J
Song, H
Ramus, SJ
Notaridou, M
Jones, C
Sher, T
Gentry-Maharaj, A
Wozniak, E
Tsai, Y-Y
Weidhaas, J
Paik, D
Van den Berg, DJ
Stram, DO
Pearce, CL
Wu, AH
Brewster, W
Anton-Culver, H
Ziogas, A
Narod, SA
Levine, DA
Kaye, SB
Brown, R
Paul, J
Flanagan, J
Sieh, W
McGuire, V
Whittemore, AS
Campbell, I
Gore, ME
Lissowska, J
Yang, HP
Medrek, K
Gronwald, J
Lubinski, J
Jakubowska, A
Le, ND
Cook, LS
Kelemen, LE
Brook-Wilson, A
Massuger, LFAG
Kiemeney, LA
Aben, KKH
Van Altena, AM
Houlston, R
Tomlinson, I
Palmieri, RT
Moorman, PG
Schildkraut, J
Iversen, ES
Phelan, C
Vierkant, RA
Cunningham, JM
Goode, EL
Fridley, BL
Kruger-Kjaer, S
Blaeker, J
Hogdall, E
Hogdall, C
Gross, J
Karlan, BY
Ness, RB
Edwards, RP
Odunsi, K
Moyisch, KB
Baker, JA
Modugno, F
Heikkinenen, T
Butzow, R
Nevanlinna, H
Leminen, A
Bogdanova, N
Antonenkova, N
Doerk, T
Hillemanns, P
Duerst, M
Runnebaum, I
Thompson, PJ
Carney, ME
Goodman, MT
Lurie, G
Wang-Gohrke, S
Hein, R
Chang-Claude, J
Rossing, MA
Cushing-Haugen, KL
Doherty, J
Chen, C
Rafnar, T
Besenbacher, S
Sulem, P
Stefansson, K
Birrer, MJ
Terry, KL
Hernandez, D
Cramer, DW
Vergote, I
Amant, F
Lambrechts, D
Despierre, E
Fasching, PA
Beckmann, MW
Thiel, FC
Ekici, AB
Chen, X
Johnatty, SE
Webb, PM
Beesley, J
Chanock, S
Garcia-Closas, M
Sellers, T
Easton, DF
Berchuck, A
Chenevix-Trench, G
Pharoah, PDP
Gayther, SA
Item Type: Journal Article
Abstract: Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer in women1. We performed a three-phase genome-wide association study of EOC survival in 8,951 individuals with EOC (cases) with available survival time data and a parallel association analysis of EOC susceptibility. Two SNPs at 19p13.11, rs8170 and rs2363956, showed evidence of association with survival (overall P = 5 × 10−4 and P = 6 × 10−4, respectively), but they did not replicate in phase 3. However, the same two SNPs demonstrated genome-wide significance for risk of serous EOC (P = 3 × 10−9 and P = 4 × 10−11, respectively). Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1-interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development.
Issue Date: 19-Sep-2010
Date of Acceptance: 30-Jul-2010
URI: http://hdl.handle.net/10044/1/40817
DOI: http://dx.doi.org/10.1038/ng.666
ISSN: 1546-1718
Publisher: Nature Publishing Group
Start Page: 880
End Page: 884
Journal / Book Title: Nature Genetics
Volume: 42
Issue: 10
Copyright Statement: © 2010 Nature America, Inc. All rights reserved.
Keywords: Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
GENETICS & HEREDITY
GENOME-WIDE ASSOCIATION
BRCA1
GENOTYPES
COMPLEX
BREAST
CELLS
Adaptor Proteins, Signal Transducing
Adenocarcinoma, Clear Cell
Adenocarcinoma, Mucinous
Biomarkers, Tumor
Case-Control Studies
Chromosomes, Human, Pair 19
Cystadenocarcinoma, Serous
Endometrial Neoplasms
Female
Gene Expression Profiling
Genetic Predisposition to Disease
Genome, Human
Genome-Wide Association Study
Genotype
Humans
Middle Aged
Oligonucleotide Array Sequence Analysis
Ovarian Neoplasms
Ovary
Polymorphism, Single Nucleotide
Tumor Cells, Cultured
Australian Ovarian Cancer Study Group
Australian Cancer Study (Ovarian Cancer)
Ovarian Cancer Association Consortium
Developmental Biology
11 Medical And Health Sciences
06 Biological Sciences
Publication Status: Published
Appears in Collections:Division of Surgery
Division of Cancer
Faculty of Medicine



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