A comparison of automated anatomical-behavioural mapping methods in a rodent model of stroke

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Title: A comparison of automated anatomical-behavioural mapping methods in a rodent model of stroke
Author(s): Crum, WR
Giampietro, VP
Smith, EJ
Gorenkova, N
Stroemer, RP
Modo, M
Item Type: Journal Article
Abstract: Neurological damage, due to conditions such as stroke, results in a complex pattern of structural changes and significant behavioural dysfunctions; the automated analysis of magnetic resonance imaging (MRI) and discovery of structural–behavioural correlates associated with these disorders remains challenging. Voxel lesion symptom mapping (VLSM) has been used to associate behaviour with lesion location in MRI, but this analysis requires the definition of lesion masks on each subject and does not exploit the rich structural information in the images. Tensor-based morphometry (TBM) has been used to perform voxel-wise structural analyses over the entire brain; however, a combination of lesion hyper-intensities and subtle structural remodelling away from the lesion might confound the interpretation of TBM. In this study, we compared and contrasted these techniques in a rodent model of stroke (n = 58) to assess the efficacy of these techniques in a challenging pre-clinical application. The results from the automated techniques were compared using manually derived region-of-interest measures of the lesion, cortex, striatum, ventricle and hippocampus, and considered against model power calculations. The automated TBM techniques successfully detect both lesion and non-lesion effects, consistent with manual measurements. These techniques do not require manual segmentation to the same extent as VLSM and should be considered part of the toolkit for the unbiased analysis of pre-clinical imaging-based studies.
Publication Date: 29-May-2013
Date of Acceptance: 16-May-2013
URI: http://hdl.handle.net/10044/1/40598
DOI: http://dx.doi.org/10.1016/j.jneumeth.2013.05.009
ISSN: 1872-678X
Publisher: Elsevier
Start Page: 170
End Page: 183
Journal / Book Title: Journal of Neuroscience Methods
Volume: 218
Issue: 2
Copyright Statement: Open access under CC BY license
Keywords: Science & Technology
Life Sciences & Biomedicine
Biochemical Research Methods
Neurosciences
Biochemistry & Molecular Biology
Neurosciences & Neurology
BIOCHEMICAL RESEARCH METHODS
NEUROSCIENCES
Voxel lesion symptom mapping
Tensor-based morphometry
Stroke
Magnetic resonance imaging
Image registration
VOXEL-BASED MORPHOMETRY
FOCAL CEREBRAL-ISCHEMIA
FALSE DISCOVERY RATE
FLUID REGISTRATION
FUNCTIONAL RECOVERY
BRAIN IMAGES
MR-IMAGES
RATS
DISEASE
REORGANIZATION
Image registration
Magnetic resonance imaging
Stroke
Tensor-based morphometry
Voxel lesion symptom mapping
Animals
Automation
Brain Mapping
Disease Models, Animal
Image Interpretation, Computer-Assisted
Magnetic Resonance Imaging
Rats
Rats, Sprague-Dawley
Stroke
Animals
Rats
Rats, Sprague-Dawley
Disease Models, Animal
Image Interpretation, Computer-Assisted
Magnetic Resonance Imaging
Brain Mapping
Automation
Stroke
Neurology & Neurosurgery
1109 Neurosciences
1702 Cognitive Science
Publication Status: Published
Appears in Collections:Division of Surgery
Division of Cancer
Faculty of Medicine



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