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Hippocampal Hypertrophy and Sleep Apnea: A Role for the Ischemic Preconditioning?

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Title: Hippocampal Hypertrophy and Sleep Apnea: A Role for the Ischemic Preconditioning?
Author(s): Rosenzweig, I
Kempton, MJ
Crum, WR
Glasser, M
Milosevic, M
Beniczky, S
Corfield, DR
Williams, SC
Morrell, MJ
Item Type: Journal Article
Abstract: The full impact of multisystem disease such as obstructive sleep apnoea (OSA) on regions of the central nervous system is debated, as the subsequent neurocognitive sequelae are unclear. Several preclinical studies suggest that its purported major culprits, intermittent hypoxia and sleep fragmentation, can differentially affect adult hippocampal neurogenesis. Although the prospective biphasic nature of chronic intermittent hypoxia in animal models of OSA has been acknowledged, so far the evidence for increased ‘compensatory’ neurogenesis in humans is uncertain. In a cross-sectional study of 32 patients with mixed severity OSA and 32 non-apnoeic matched controls inferential analysis showed bilateral enlargement of hippocampi in the OSA group. Conversely, a trend for smaller thalami in the OSA group was noted. Furthermore, aberrant connectivity between the hippocampus and the cerebellum in the OSA group was also suggested by the correlation analysis. The role for the ischemia/hypoxia preconditioning in the neuropathology of OSA is herein indicated, with possible further reaching clinical implications.
Publication Date: 13-Dec-2013
Date of Acceptance: 30-Oct-2013
URI: http://hdl.handle.net/10044/1/40595
DOI: http://dx.doi.org/10.1371/journal.pone.0083173
ISSN: 1932-6203
Publisher: Public Library of Science
Journal / Book Title: PLOS One
Volume: 8
Issue: 12
Copyright Statement: © 2013 Rosenzweig et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
MULTIDISCIPLINARY SCIENCES
BRAIN STRUCTURAL-CHANGES
INTERMITTENT HYPOXIA
NEUROCOGNITIVE FUNCTION
AUTOMATIC SEGMENTATION
ADULT NEUROGENESIS
CEREBELLAR ATROPHY
STROKE
RATS
MORPHOLOGY
DISORDER
Adult
Female
Hippocampus
Humans
Hypertrophy
Ischemic Preconditioning
Male
Middle Aged
Sleep Apnea Syndromes
Hippocampus
Humans
Sleep Apnea Syndromes
Hypertrophy
Ischemic Preconditioning
Adult
Middle Aged
Female
Male
General Science & Technology
MD Multidisciplinary
Publication Status: Published
Article Number: e83173
Appears in Collections:Division of Surgery
National Heart and Lung Institute
Airway Disease
Division of Cancer
Faculty of Medicine



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