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Endobronchial valves for patients with heterogeneous emphysema and without interlobar collateral ventilation – open label treatment following the BeLieVeR-HIFi study

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Title: Endobronchial valves for patients with heterogeneous emphysema and without interlobar collateral ventilation – open label treatment following the BeLieVeR-HIFi study
Authors: Hopkinson, NS
Polkey
Shah, P
Hind
Item Type: Journal Article
Abstract: Outcomes in early trials of bronchoscopic lung volume reduction using endobronchial valves for the treatment of patients with advanced emphysema were inconsistent. However improvements in patient selection with focus on excluding those with interlobar collateral ventilation and homogeneous emphysema resulted in significant benefits in the BeLieVeR-HIFi study compared to sham treated controls. In this manuscript we present data from the control patients in the BeLieVeR-HIFi study who went on to have open label endobronchial valve treatment after completion of the clinical trial (n=12), combined with data from those in the treatment arm who did not have collateral ventilation (n=19). Three months after treatment the forced expiratory volume in the 1st second increased by 27.3(36.4)%, residual volume reduced by 0.49(0.76)L, the 6 minute walk distance increased by 32.6(68.7) m, and the St George Respiratory Questionnaire for COPD score improved by 8.2(20.2) points. These data extend the evidence for endobronchial valve placement in appropriately selected patients with COPD.
Issue Date: 20-Dec-2016
Date of Acceptance: 19-Sep-2016
URI: http://hdl.handle.net/10044/1/40489
DOI: https://dx.doi.org/10.1136/thoraxjnl-2016-208865
ISSN: 1468-3296
Publisher: BMJ Publishing Group
Start Page: 277
End Page: 279
Journal / Book Title: Thorax
Volume: 72
Copyright Statement: This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/
Sponsor/Funder: National Institute for Health Research
Funder's Grant Number: UD99999959
Keywords: Science & Technology
Life Sciences & Biomedicine
Respiratory System
LUNG-VOLUME-REDUCTION
THERAPY
SURVIVAL
TRIAL
COPD
Bronchoscopy
Emphysema
Lung Volume Reduction Surgery
Aged
Double-Blind Method
Female
Forced Expiratory Volume
Humans
Lung Volume Measurements
Male
Middle Aged
Patient Selection
Prostheses and Implants
Prosthesis Implantation
Pulmonary Emphysema
Treatment Outcome
1103 Clinical Sciences
Publication Status: Published
Appears in Collections:National Heart and Lung Institute
Airway Disease
Faculty of Medicine



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