A composite hydrogel for brain tissue phantoms

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Title: A composite hydrogel for brain tissue phantoms
Author(s): Forte, AE
Galvan, S
Manieri, F
Rodriguez y Baena, F
Dini, D
Item Type: Journal Article
Abstract: Synthetic phantoms are valuable tools for training, research and development in traditional and computer aided surgery, but complex organs, such as the brain, are difficult to replicate. Here, we present the development of a new composite hydrogel capable of mimicking the mechanical response of brain tissue under loading. Our results demonstrate how the combination of two different hydrogels, whose synergistic interaction results in a highly tunable blend, produces a hybrid material that closely matches the strongly dynamic and non-linear response of brain tissue. The new synthetic material is inexpensive, simple to prepare, and its constitutive components are both widely available and biocompatible. Our investigation of the properties of this engineered tissue, using both small scale testing and life-sized brain phantoms, shows that it is suitable for reproducing the brain shift phenomenon and brain tissue response to indentation and palpation.
Publication Date: 19-Sep-2016
Date of Acceptance: 17-Sep-2016
ISSN: 0264-1275
Publisher: Elsevier
Start Page: 227
End Page: 238
Journal / Book Title: Materials and Design
Volume: 112
Replaces: 10044/1/41101
Sponsor/Funder: Commission of the European Communities
Engineering & Physical Science Research Council (E
Commission of the European Communities
Engineering & Physical Science Research Council (EPSRC)
Funder's Grant Number: 270460
Copyright Statement: Available under a CC BY license.
Keywords: Materials
Materials Engineering
Mechanical Engineering
Publication Status: Published
Appears in Collections:Faculty of Engineering
Mechanical Engineering
Faculty of Natural Sciences

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