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Adult lung function and long-term air pollution exposure. ESCAPE: a multicentre cohort study and meta-analysis

Title: Adult lung function and long-term air pollution exposure. ESCAPE: a multicentre cohort study and meta-analysis
Authors: Adam, M
Schikowski, T
Carsin, AE
Cai, Y
Jacquemin, B
Sanchez, M
Vierkötter, A
Marcon, A
Keidel, D
Sugiri, D
Al Kanani, Z
Nadif, R
Siroux, V
Hardy, R
Kuh, D
Rochat, T
Bridevaux, P-O
Eeftens, M
Tsai, M-Y
Villani, S
Phuleria, HC
Birk, M
Cyrys, J
Cirach, M
De Nazelle, A
Nieuwenhuijsen, MJ
Forsberg, B
De Hoogh, K
Declerq, C
Bono, R
Piccioni, P
Quass, U
Heinrich, J
Jarvis, D
Pin, I
Beelen, R
Hoek, G
Brunekreef, B
Schindler, C
Sunyer, J
Krämer, U
Kauffmann, F
Hansell, AL
Künzli, N
Probst-Hensch, N
Item Type: Journal Article
Abstract: The chronic impact of ambient air pollutants on lung function in adults is not fully understood. The objective of this study was to investigate the association of long-term exposure to ambient air pollution with lung function in adult participants from five cohorts in the European Study of Cohorts for Air Pollution Effects (ESCAPE).Residential exposure to nitrogen oxides (NO2, NOx) and particulate matter (PM) was modelled and traffic indicators were assessed in a standardised manner. The spirometric parameters forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) from 7613 subjects were considered as outcomes. Cohort-specific results were combined using meta-analysis.We did not observe an association of air pollution with longitudinal change in lung function, but we observed that a 10 μg·m−3 increase in NO2 exposure was associated with lower levels of FEV1 (−14.0 mL, 95%CI −25.8– −2.1) and FVC (−14.9 mL, 95% CI −28.7– −1.1). An increase of 10 μg·m−3 in PM10, but not other PM metrics (PM2.5, coarse fraction of PM, PM absorbance), was associated with a lower level of FEV1 (−44.6 mL, 95% CI −85.4– −3.8) and FVC (−59.0 mL, 95% CI −112.3– −5.6). The associations were particularly strong in obese persons.This study adds to the evidence for an adverse association of ambient air pollution with lung function in adults at very low levels in Europe.
Issue Date: 31-Dec-2014
Date of Acceptance: 24-Jul-2014
URI: http://hdl.handle.net/10044/1/40410
DOI: http://dx.doi.org/10.1183/09031936.00130014
ISSN: 1399-3003
Publisher: European Respiratory Society
Start Page: 38
End Page: 50
Journal / Book Title: European Respiratory Journal
Volume: 45
Issue: 1
Copyright Statement: © ERS 2015. ERJ Open articles are open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
Sponsor/Funder: Medical Research Council (MRC)
Funder's Grant Number: G0801056/1
Keywords: Science & Technology
Life Sciences & Biomedicine
Respiratory System
USE REGRESSION-MODELS
BODY-MASS INDEX
PM2.5 ABSORBENCY
FUNCTION DECLINE
OZONE EXPOSURE
OBESITY
NO2
PROJECT
AREAS
INFLAMMATION
Adult
Aged
Air Pollutants
Air Pollution
Environmental Exposure
Environmental Monitoring
Europe
Female
Forced Expiratory Volume
Humans
Lung
Male
Middle Aged
Multicenter Studies as Topic
Nitrogen Oxides
Particulate Matter
Respiratory Physiological Phenomena
Lung
Humans
Nitrogen Oxides
Air Pollutants
Forced Expiratory Volume
Air Pollution
Environmental Exposure
Environmental Monitoring
Adult
Aged
Middle Aged
Europe
Female
Male
Particulate Matter
Multicenter Studies as Topic
Respiratory Physiological Phenomena
Respiratory System
11 Medical And Health Sciences
Publication Status: Published
Appears in Collections:Infectious Disease Epidemiology
National Heart and Lung Institute
Centre for Environmental Policy
Faculty of Medicine
Faculty of Natural Sciences
Epidemiology, Public Health and Primary Care



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