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25-Hydroxyvitamin D Concentration and Leukocyte Telomere Length in Young Adults: Findings From the Northern Finland Birth Cohort 1966

Title: 25-Hydroxyvitamin D Concentration and Leukocyte Telomere Length in Young Adults: Findings From the Northern Finland Birth Cohort 1966
Author(s): Williams, DM
Palaniswamy, S
Sebert, S
Buxton, JL
Blakemore, AIF
Hyppoenen, E
Jarvelin, M-R
Item Type: Journal Article
Abstract: Higher vitamin D status, lower adiposity, and longer telomere length are each reportedly associated with lower risk of several chronic diseases and all-cause mortality. However, direct relationships between vitamin D status (measured by circulating 25-hydroxyvitamin D (25(OH)D) concentration), adiposity, and telomere length are not well established. We conducted a cross-sectional analysis of associations of 25(OH)D and body mass index (BMI; weight (kg)/height (m)2) with mean relative leukocyte telomere length (LTL) using data gathered on 5,096 participants from Northern Finland Birth Cohort 1966 at age 31 years (1997). 25(OH)D was not associated with LTL in either basic or confounder/mediator-adjusted models. BMI was inversely associated with LTL after adjustment for potential confounding by age, sex, socioeconomic position, physical activity, diet, smoking, alcohol intake, and use of oral contraceptives (per 1-unit increase in BMI, mean difference in LTL = −0.4%, 95% confidence interval: −0.6, −0.2). The BMI-LTL association was also independent of 25(OH)D and was attenuated slightly, but remained, after adjustment for C-reactive protein, a marker of low-grade inflammation (mean difference in LTL = −0.3%, 95% confidence interval −0.6, −0.1). These findings suggest that vitamin D status is unlikely to be an important determinant of LTL, at least by young adulthood. Inflammation may partly mediate associations of adiposity with LTL.
Publication Date: 20-Jan-2016
Date of Acceptance: 28-Jul-2015
URI: http://hdl.handle.net/10044/1/40397
DOI: http://dx.doi.org/10.1093/aje/kwv203
ISSN: 1476-6256
Publisher: Oxford University Press
Start Page: 191
End Page: 198
Journal / Book Title: American Journal of Epidemiology
Volume: 183
Issue: 3
Sponsor/Funder: Wellcome Trust
Funder's Grant Number: 088431/Z/09/Z
Copyright Statement: © The Author 2016. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Science & Technology
Life Sciences & Biomedicine
Public, Environmental & Occupational Health
biological aging
Northern Finland Birth Cohorts
telomere length
vitamin D
VITAMIN-D STATUS
BODY-MASS INDEX
MENDELIAN RANDOMIZATION
CARDIOVASCULAR-DISEASE
D DEFICIENCY
ASSOCIATION
RISK
METAANALYSIS
WOMEN
MORTALITY
Northern Finland Birth Cohorts
biological aging
telomere length
vitamin D
Adiposity
Adult
Body Mass Index
C-Reactive Protein
Cross-Sectional Studies
Female
Finland
Humans
Leukocytes
Male
Prospective Studies
Telomere Homeostasis
Vitamin D
Leukocytes
Humans
Vitamin D
C-Reactive Protein
Body Mass Index
Prospective Studies
Cross-Sectional Studies
Adult
Finland
Female
Male
Adiposity
Telomere Homeostasis
Epidemiology
11 Medical And Health Sciences
01 Mathematical Sciences
Publication Status: Published
Appears in Collections:Department of Medicine
Faculty of Medicine
Epidemiology, Public Health and Primary Care



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