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Multidimensional analysis of the effect of occupational exposure to organic solvents on lung cancer risk: the ICARE study

Title: Multidimensional analysis of the effect of occupational exposure to organic solvents on lung cancer risk: the ICARE study
Author(s): Mattei, F
Liverani, S
Guida, F
Matrat, M
Cenee, S
Azizi, L
Menvielle, G
Sanchez, M
Pilorget, C
Lapotre-Ledoux, B
Luce, D
Richardson, S
Stucker, I
Item Type: Journal Article
Abstract: Background The association between lung cancer and occupational exposure to organic solvents is discussed. Since different solvents are often used simultaneously, it is difficult to assess the role of individual substances. Objectives The present study is focused on an in-depth investigation of the potential association between lung cancer risk and occupational exposure to a large group of organic solvents, taking into account the well-known risk factors for lung cancer, tobacco smoking and occupational exposure to asbestos. Methods We analysed data from the Investigation of occupational and environmental causes of respiratory cancers (ICARE) study, a large French population-based case–control study, set up between 2001 and 2007. A total of 2276 male cases and 2780 male controls were interviewed, and long-life occupational history was collected. In order to overcome the analytical difficulties created by multiple correlated exposures, we carried out a novel type of analysis based on Bayesian profile regression. Results After analysis with conventional logistic regression methods, none of the 11 solvents examined were associated with lung cancer risk. Through a profile regression approach, we did not observe any significant association between solvent exposure and lung cancer. However, we identified clusters at high risk that are related to occupations known to be at risk of developing lung cancer, such as painters. Conclusions Organic solvents do not appear to be substantial contributors to the occupational risk of lung cancer for the occupations known to be at risk.
Publication Date: 23-Feb-2016
Date of Acceptance: 5-Feb-2016
URI: http://hdl.handle.net/10044/1/40390
DOI: http://dx.doi.org/10.1136/oemed-2015-103177
ISSN: 1470-7926
Publisher: BMJ Publishing Group
Start Page: 368
End Page: 377
Journal / Book Title: Occupational and Environmental Medicine
Volume: 73
Issue: 6
Copyright Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Keywords: Science & Technology
Life Sciences & Biomedicine
Public, Environmental & Occupational Health
CHLORINATED SOLVENTS
PROFILE REGRESSION
INHALED BENZENE
POPULATION
MICE
CARCINOGENICITY
WORKERS
MORTALITY
SMOKING
FRANCE
Bayesian profile regression
Lung cancer
Occupational exposure
Organic solvents
ICARE Study Group
Environmental & Occupational Health
1103 Clinical Sciences
1117 Public Health And Health Services
1599 Other Commerce, Management, Tourism And Services
Publication Status: Published
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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