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Fiber intake modulates the association of alcohol intake with breast cancer

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Title: Fiber intake modulates the association of alcohol intake with breast cancer
Authors: Romieu, I
Ferrari, P
Chajès, V
De Batlle, J
Biessy, C
Scoccianti, C
Dossus, L
Boutron, MC
Bastide, N
Overvad, K
Olsen, A
Tjønneland, A
Kaaks, R
Boeing, H
Trichopoulou, A
Lagiou, P
Trichopoulos, D
Palli, D
Sieri, S
Tumino, R
Vineis, P
Panico, S
Bueno-de-Mesquita, HB
Gils, CH
Peeters, PH
Lund, E
Skeie, G
Weiderpass, E
Quirós, JR
Chirlaque, MD
Ardanaz, E
Sánchez, MJ
Duell, EJ
Amiano Etxezarreta, P
Borgquist, S
Hallmans, G
Johansson, I
Nilsson, LM
Khaw, KT
Wareham, N
Key, TJ
Travis, RC
Murphy, N
Wark, PA
Riboli, E
Item Type: Journal Article
Abstract: Alcohol intake has been related to an increased risk of breast cancer (BC) while dietary fiber intake has been inversely associated to BC risk. A beneficial effect of fibers on ethanol carcinogenesis through their impact on estrogen levels is still controversial. We investigated the role of dietary fiber as a modifying factor of the association of alcohol and breast cancer using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 334,850 women aged 35-70 years at baseline enrolled in the ten countries of the EPIC study and followed up for 11.0 years on average. Information on fiber and alcohol intake at baseline and average lifetime alcohol intake were calculated from country-specific dietary and lifestyle questionnaires. Hazard ratios (HR) of developing invasive breast cancer according to different levels of alcohol and fiber intake were computed. During 3,670,439 person-years, 11,576 incident breast cancer cases were diagnosed. For subjects with low intake of fiber (<18.5 g/day), the risk of BC per 10g/day of alcohol intake was 1.06 (1.03-1.08) while among subjects with high intake of fiber (>24.2 g/day) the risk of BC was 1.02 (0.99-1.05) (test for interaction p=0.011). This modulating effect was stronger for fiber from vegetables. Our results suggest that fiber intake may modulate the positive association of alcohol intake and BC.
Issue Date: 21-Nov-2016
Date of Acceptance: 13-Jan-2016
URI: http://hdl.handle.net/10044/1/40269
DOI: https://dx.doi.org/10.1002/ijc.30415
ISSN: 1097-0215
Publisher: Wiley
Start Page: 316
End Page: 321
Journal / Book Title: International Journal of Cancer
Volume: 140
Issue: 2
Copyright Statement: © 2016 UICC. This is the accepted version of the following article: Romieu, I. et al. (2016), Fiber intake modulates the association of alcohol intake with breast cancer. Int. J. Cancer., which has been published in final form at http://dx.doi.org/10.1002/ijc.30415.
Sponsor/Funder: University Medical Center Utrecht
Imperial College Trust
Funder's Grant Number: N/A
P47328
Keywords: alcohol
breast cancer
epidemiology
nutrition
Oncology & Carcinogenesis
1112 Oncology And Carcinogenesis
Publication Status: Published
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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