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Flow velocity mapping using high frame-rate plane wave ultrasound and microbubble contrast agents – methods and initial in vitro and in vivo evaluation

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Title: Flow velocity mapping using high frame-rate plane wave ultrasound and microbubble contrast agents – methods and initial in vitro and in vivo evaluation
Authors: Leow, C
Tang, M
Item Type: Journal Article
Abstract: Ultrasound imaging is the most widely used method for visualising and quantifying blood flow in medical practice but existing techniques have various limitations in terms of imaging sensitivity, field of view, flow angle dependence and imaging depth. In this study, we developed an ultrasound imaging velocimetry approach capable of visualising and quantifying dynamic flow, by combining high frame-rate plane wave ultrasound imaging, microbubble contrast agents, pulse inversion contrast imaging and speckle tracking algorithms. The system has been initially evaluated in vitro on both straight and carotidmimicking vessels with steady and pulsatile flows, and in vivo in the rabbit aorta. Colour and spectral Doppler measurements were also made. Initial flow mapping results were compared with theoretical prediction and reference Doppler measurements and demonstrate the potential of the new system as a highly sensitive, accurate, angle-independent and full fieldof-view velocity mapping tool capable of tracking and quantifying fast and dynamic flows.
Issue Date: 12-Aug-2015
Date of Acceptance: 16-Jun-2015
URI: http://hdl.handle.net/10044/1/40194
DOI: https://dx.doi.org/10.1016/j.ultrasmedbio.2015.06.012
ISSN: 1879-291X
Publisher: Elsevier
Start Page: 2913
End Page: 2925
Journal / Book Title: Ultrasound in Medicine & Biology
Volume: 41
Issue: 11
Copyright Statement: Creative Commons Attribution 4.0 International (CC BY 4.0)
Sponsor/Funder: British Heart Foundation
Engineering & Physical Science Research Council (E
Engineering & Physical Science Research Council (EPSRC)
Funder's Grant Number: RG/11/5/28743
EP/K503733/1
EP/M011933/1
Keywords: Science & Technology
Technology
Life Sciences & Biomedicine
Acoustics
Radiology, Nuclear Medicine & Medical Imaging
Flow
Microbubble contrast agents
Ultrafast ultrasound imaging
Ultrasound imaging velocimetry
Echo-particle image velocimetry
Atherosclerosis
Image tracking
VECTOR DOPPLER
SPECKLE TRACKING
SHEAR-STRESS
BLOOD-FLOW
CROSS-CORRELATION
CAROTID-ARTERY
VELOCIMETRY
AGENTS
BEAM
VALIDATION
Algorithms
Animals
Aorta
Blood Flow Velocity
Contrast Media
Echocardiography, Doppler
Image Enhancement
Image Interpretation, Computer-Assisted
Microbubbles
Phantoms, Imaging
Rabbits
Reproducibility of Results
Sensitivity and Specificity
1103 Clinical Sciences
Publication Status: Published
Appears in Collections:Faculty of Engineering
Bioengineering



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