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What is the function of mitochondrial networks? A theoretical assessment of hypotheses and proposal for future research

Title: What is the function of mitochondrial networks? A theoretical assessment of hypotheses and proposal for future research
Authors: Hoitzing, H
Johnston, IG
Jones, NS
Item Type: Journal Article
Abstract: Mitochondria can change their shape from discrete isolated organelles to a large continuous reticulum. The cellular advantages underlying these fused networks are still incompletely understood. In this paper, we describe and compare hypotheses regarding the function of mitochondrial networks. We use mathematical and physical tools both to investigate existing hypotheses and to generate new ones, and we suggest experimental and modelling strategies. Among the novel insights we underline from this work are the possibilities that (i) selective mitophagy is not required for quality control because selective fusion is sufficient; (ii) increased connectivity may have non-linear effects on the diffusion rate of proteins; and (iii) fused networks can act to dampen biochemical fluctuations. We hope to convey to the reader that quantitative approaches can drive advances in the understanding of the physiological advantage of these morphological changes.
Issue Date: 3-Apr-2015
Date of Acceptance: 3-Apr-2015
URI: http://hdl.handle.net/10044/1/40177
DOI: http://dx.doi.org/10.1002/bies.201400188
ISSN: 1521-1878
Publisher: Wiley-VCH Verlag
Start Page: 687
End Page: 700
Journal / Book Title: Bioessays
Volume: 37
Issue: 6
Copyright Statement: © 2015 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: Medical Research Council (MRC)
Funder's Grant Number: MR/J013617/1
Keywords: Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Biology
Life Sciences & Biomedicine - Other Topics
hypotheses
mathematical biology
mitochondrial dynamics
mitochondrial networks
non-linearities
ultrastructure
CYTOCHROME-C RELEASE
OXIDATIVE-PHOSPHORYLATION
ENERGY-METABOLISM
CALCIUM-IONS
TRANSMITTING CABLES
MAMMALIAN-CELLS
MTDNA MUTATIONS
QUALITY-CONTROL
FISSION-FUSION
ATP-SYNTHESIS
Animals
Electron Transport Chain Complex Proteins
Energy Metabolism
Humans
Mitochondria
Mitochondrial Degradation
Mitochondrial Dynamics
Developmental Biology
06 Biological Sciences
11 Medical And Health Sciences
17 Psychology And Cognitive Sciences
Publication Status: Published
Appears in Collections:Mathematics
Applied Mathematics and Mathematical Physics
Faculty of Natural Sciences



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