Aerobic oxidations in flow: opportunities for the fine chemicals and pharmaceuticals industries

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Title: Aerobic oxidations in flow: opportunities for the fine chemicals and pharmaceuticals industries
Author(s): Hii, KM
Hellgardt, K
Gavriilidis, A
Constantinou, A
Hutchings, G
Brett, G
Kuhn, S
Marsden, SP
Item Type: Journal Article
Abstract: Molecular oxygen is without doubt the greenest oxidant for redox reactions, yet aerobic oxidation is one of the most challenging to perform with good chemoselectivity, particularly on an industrial scale. This collaborative review (between teams of chemists and chemical engineers) describes the current scientific and operational hurdles that prevent the utilisation of these reactions for the production of speciality chemicals and active pharmaceutical ingredients (APIs). The safety aspects of these reactions are discussed, followed by an overview of (continuous flow) reactors suitable for aerobic oxidation reactions that can be applied on scale. Some examples of how these reactions are currently performed in the industrial laboratory (in batch and in flow) are presented, with particular focus on the scale-up strategy. Last but not least, further challenges and future perspectives are presented in the concluding remarks.
Publication Date: 22-Sep-2016
Date of Acceptance: 13-Sep-2016
URI: http://hdl.handle.net/10044/1/40123
DOI: https://dx.doi.org/10.1039/C6RE00155F
ISSN: 2058-9883
Publisher: Royal Society of Chemistry
Start Page: 595
End Page: 612
Journal / Book Title: Reaction Chemistry & Engineering
Volume: 1
Copyright Statement: This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Sponsor/Funder: Engineering & Physical Science Research Council (E
Funder's Grant Number: EP/L003279/1
Keywords: Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
MOLECULAR-OXYGEN
SELECTIVE OXIDATION
VISIBLE-LIGHT
BENZYL ALCOHOL
CATALYZED OXIDATION
HYDROGEN-PEROXIDE
ORGANIC-SYNTHESIS
CARBON-DIOXIDE
MASS-TRANSFER
TAYLOR FLOW
Publication Status: Published
Appears in Collections:Faculty of Engineering
Chemistry
Catalysis and Advanced Materials
Chemical Engineering
Faculty of Natural Sciences



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