A bisphosphonate for F-19-magnetic resonance imaging

File Description SizeFormat 
1-s2.0-S0022113916300471-main.pdfPublished version1.29 MBAdobe PDFView/Open
Title: A bisphosphonate for F-19-magnetic resonance imaging
Authors: Kenny, GD
Shaw, KP
Sivachelvam, S
White, AJP
Botnar, RM
De Rosales, RTM
Item Type: Journal Article
Abstract: 19F-magnetic resonance imaging (MRI) is a promising technique that may allow us to measure the concentration of exogenous fluorinated imaging probes quantitatively in vivo. Here, we describe the synthesis and characterisation of a novel geminal bisphosphonate (19F-BP) that contains chemically-equivalent fluorine atoms that show a single and narrow 19F resonance and a bisphosphonate group that may be used for labelling inorganic materials based in calcium phosphates and metal oxides. The potential of 19F-BP to provide contrast was analysed in vitro and in vivo using 19F-MRI. In vitro studies demonstrated the potential of 19F-BP as an MRI contrast agent in the millimolar concentration range with signal-to-noise ratios (SNR) comparable to previously reported fluorinated probes. The preliminary in vivo MRI study reported here allowed us to visualise the biodistribution of 19F-BP, showing uptake in the liver and in the bladder/urinary system areas. However, bone uptake was not observed. In addition, 19F-BP showed undesirable toxicity effects in mice that prevent further studies with this compound at the required concentrations for MRI contrast. This study highlights the importance of developing 19F MRI probes with the highest signal intensity achievable.
Issue Date: 26-Feb-2016
Date of Acceptance: 24-Feb-2016
URI: http://hdl.handle.net/10044/1/40099
DOI: http://dx.doi.org/10.1016/j.jfluchem.2016.02.008
ISSN: 1873-3328
Publisher: Elsevier
Start Page: 58
End Page: 64
Journal / Book Title: Journal of Fluorine Chemistry
Volume: 184
Copyright Statement: © 2016 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Science & Technology
Physical Sciences
Chemistry, Inorganic & Nuclear
Chemistry, Organic
Bisphosphonates (BPs)
Magnetic resonance imaging (MRI)
Preclinical imaging
Fluorinated bisphosphonate
Organic Chemistry
0302 Inorganic Chemistry
0305 Organic Chemistry
Publication Status: Published
Appears in Collections:Chemistry
Faculty of Natural Sciences

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Creative Commonsx