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A genome-wide association study of marginal zone lymphoma shows association to the HLA region

Title: A genome-wide association study of marginal zone lymphoma shows association to the HLA region
Authors: Vijai, J
Wang, Z
Berndt, SI
Skibola, CF
Slager, SL
De Sanjose, S
Melbye, M
Glimelius, B
Bracci, PM
Conde, L
Birmann, BM
Wang, SS
Brooks-Wilson, AR
Lan, Q
De Bakker, PIW
Vermeulen, RCH
Portlock, C
Ansell, SM
Link, BK
Riby, J
North, KE
Gu, J
Hjalgrim, H
Cozen, W
Becker, N
Teras, LR
Spinelli, JJ
Turner, J
Zhang, Y
Purdue, MP
Giles, GG
Kelly, RS
Zeleniuch-Jacquotte, A
Ennas, MG
Monnereau, A
Bertrand, KA
Albanes, D
Lightfoot, T
Yeager, M
Chung, CC
Burdett, L
Hutchinson, A
Lawrence, C
Montalvan, R
Liang, L
Huang, J
Ma, B
Villano, DJ
Maria, A
Corines, M
Thomas, T
Novak, AJ
Dogan, A
Liebow, M
Thompson, CA
Witzig, TE
Habermann, TM
Weiner, GJ
Smith, MT
Holly, EA
Jackson, RD
Tinker, LF
Ye, Y
Adami, H-O
Smedby, KE
De Roos, AJ
Hartge, P
Morton, LM
Severson, RK
Benavente, Y
Boffetta, P
Brennan, P
Foretova, L
Maynadie, M
Mckay, J
Staines, A
Diver, WR
Vajdic, CM
Armstrong, BK
Kricker, A
Zheng, T
Holford, TR
Severi, G
Vineis, P
Ferri, GM
Ricco, R
Miligi, L
Clavel, J
Giovannucci, E
Kraft, P
Virtamo, J
Smith, A
Kane, E
Roman, E
Chiu, BCH
Fraumeni, JF
Wu, X
Cerhan, JR
Offit, K
Chanock, SJ
Rothman, N
Nieters, A
Item Type: Journal Article
Abstract: Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10−15) and HLA-B (rs2922994, P=2.43 × 10−9) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.
Issue Date: 8-Jan-2015
Date of Acceptance: 4-Nov-2014
URI: http://hdl.handle.net/10044/1/39941
DOI: http://dx.doi.org/10.1038/ncomms6751
ISSN: 2041-1723
Publisher: Nature Publishing Group
Journal / Book Title: Nature Communications
Volume: 6
Copyright Statement: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
NON-HODGKIN-LYMPHOMA
EPIDEMIOLOGIC RESEARCH
RHEUMATOID-ARTHRITIS
SUSCEPTIBILITY LOCI
FOLLICULAR LYMPHOMA
GASTRIC LYMPHOMA
CELL DEVELOPMENT
GENE-EXPRESSION
RISK LOCI
CLASSIFICATION
Computational Biology
European Continental Ancestry Group
Genome-Wide Association Study
Genotype
Humans
Lymphoma, B-Cell, Marginal Zone
Major Histocompatibility Complex
Membrane Glycoproteins
Polymorphism, Single Nucleotide
Humans
Membrane Glycoproteins
Computational Biology
Major Histocompatibility Complex
Genotype
Polymorphism, Single Nucleotide
European Continental Ancestry Group
Lymphoma, B-Cell, Marginal Zone
Genome-Wide Association Study
MD Multidisciplinary
Publication Status: Published
Article Number: 5751
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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