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4D flow cardiovascular magnetic resonance consensus statement

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Title: 4D flow cardiovascular magnetic resonance consensus statement
Author(s): Dyverfeldt, P
Bissell, M
Barker, AJ
Bolger, AF
Carlhall, C-J
Ebbers, T
Francios, CJ
Frydrychowicz, A
Geiger, J
Giese, D
Hope, MD
Kilner, PJ
Kozerke, S
Myerson, S
Neubauer, S
Wieben, O
Markl, M
Item Type: Journal Article
Abstract: Pulsatile blood flow through the cavities of the heart and great vessels is time-varying and multidirectional. Access to all regions, phases and directions of cardiovascular flows has formerly been limited. Four-dimensional (4D) flow cardiovascular magnetic resonance (CMR) has enabled more comprehensive access to such flows, with typical spatial resolution of 1.5×1.5×1.5 – 3×3×3 mm3, typical temporal resolution of 30–40 ms, and acquisition times in the order of 5 to 25 min. This consensus paper is the work of physicists, physicians and biomedical engineers, active in the development and implementation of 4D Flow CMR, who have repeatedly met to share experience and ideas. The paper aims to assist understanding of acquisition and analysis methods, and their potential clinical applications with a focus on the heart and greater vessels. We describe that 4D Flow CMR can be clinically advantageous because placement of a single acquisition volume is straightforward and enables flow through any plane across it to be calculated retrospectively and with good accuracy. We also specify research and development goals that have yet to be satisfactorily achieved. Derived flow parameters, generally needing further development or validation for clinical use, include measurements of wall shear stress, pressure difference, turbulent kinetic energy, and intracardiac flow components. The dependence of measurement accuracy on acquisition parameters is considered, as are the uses of different visualization strategies for appropriate representation of time-varying multidirectional flow fields. Finally, we offer suggestions for more consistent, user-friendly implementation of 4D Flow CMR acquisition and data handling with a view to multicenter studies and more widespread adoption of the approach in routine clinical investigations.
Publication Date: 10-Aug-2015
Date of Acceptance: 17-Jul-2015
URI: http://hdl.handle.net/10044/1/39465
DOI: http://dx.doi.org/10.1186/s12968-015-0174-5
ISSN: 1532-429X
Publisher: BioMed Central
Journal / Book Title: Journal of Cardiovascular Magnetic Resonance
Volume: 17
Sponsor/Funder: British Heart Foundation
Funder's Grant Number: PG/08/122/263
Copyright Statement: © Dyverfeldt et al. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Keywords: Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Radiology, Nuclear Medicine & Medical Imaging
Cardiovascular System & Cardiology
4D Flow CMR
4D Flow MRI
Phase-contrast magnetic resonance imaging
MR flow imaging
Hemodynamics
Flow visualization
Flow quantification
Recommendations
Clinical
Cardiovascular
PHASE-CONTRAST MRI
WALL SHEAR-STRESS
BICUSPID AORTIC-VALVE
IN-VIVO-VALIDATION
COMPUTATIONAL FLUID-DYNAMICS
PULSE-WAVE VELOCITY
K-T BLAST
SENSITIVE 4-DIMENSIONAL MRI
TURBULENT KINETIC-ENERGY
CORONARY-ARTERY-DISEASE
Aorta
Blood Flow Velocity
Cardiovascular Diseases
Cardiovascular System
Consensus
Coronary Circulation
Humans
Image Interpretation, Computer-Assisted
Magnetic Resonance Angiography
Myocardial Perfusion Imaging
Predictive Value of Tests
Pulsatile Flow
Time Factors
Cardiovascular System
Aorta
Humans
Cardiovascular Diseases
Image Interpretation, Computer-Assisted
Magnetic Resonance Angiography
Blood Flow Velocity
Predictive Value of Tests
Consensus
Coronary Circulation
Pulsatile Flow
Time Factors
Myocardial Perfusion Imaging
Nuclear Medicine & Medical Imaging
1102 Cardiovascular Medicine And Haematology
Publication Status: Published
Article Number: 72
Appears in Collections:National Heart and Lung Institute
Faculty of Medicine



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