Synchrotron imaging assessment of bone quality

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Title: Synchrotron imaging assessment of bone quality
Authors: Ma, S
Boughton, O
Karunaratne, A
Jin, A
Cobb, JP
Hansen, U
Abel, RL
Item Type: Journal Article
Abstract: Bone is a complex hierarchical structure and its principal function is to resist mechanical forces and fracture. Bone strength depends not only on the quantity of bone tissue but also on the shape and hierarchical structure. The hierarchical levels are interrelated, especially the micro-architecture, collagen and mineral components; hence analysis of their specific roles in bone strength and stiffness is difficult. Synchrotron imaging technologies including micro-CT and small/wide angle X-Ray scattering/diffraction are becoming increasingly popular for studying bone because the images can resolve deformations in the micro-architecture and collagen-mineral matrix under in situ mechanical loading. Synchrotron cannot be directly applied in-vivo due to the high radiation dose but will allow researchers to carry out systematic multifaceted studies of bone ex-vivo. Identifying characteristics of aging and disease will underpin future efforts to generate novel devices and interventional therapies for assessing and promoting healthy aging. With our own research work as examples, this paper introduces how synchrotron imaging technology can be used with in-situ testing in bone research.
Issue Date: 7-Sep-2016
Date of Acceptance: 18-Aug-2016
DOI: 10.1007/s12018-016-9223-3
ISSN: 1559-0119
Publisher: Springer
Start Page: 150
End Page: 160
Journal / Book Title: Clinical Reviews in Bone and Mineral Metabolism
Volume: 14
Issue: 3
Copyright Statement: © The Author(s) 2016. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Sponsor/Funder: Science and Technology Facilities Council (STFC)
The Sackler Trust
Imperial College Healthcare NHS Trust- BRC Funding
National Institute for Health Research
Funder's Grant Number: 4070103442
RDB04 79560
Keywords: Endocrinology & Metabolism
Publication Status: Published
Appears in Collections:Faculty of Engineering
Mechanical Engineering
Division of Surgery
Faculty of Medicine

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