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Aurora-A Kinase: A Potent Oncogene and Target for Cancer Therapy

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Title: Aurora-A Kinase: A Potent Oncogene and Target for Cancer Therapy
Authors: Yan, M
Wang, C
He, B
Yang, M
Tong, M
Long, Z
Liu, B
Peng, F
Xu, L
Zhang, Y
Liang, D
Lei, H
Subrata, S
Kelley, KW
Lam, EW
Jin, B
Liu, Q
Item Type: Journal Article
Abstract: The Aurora kinase family is comprised of three serine/threonine kinases, Aurora-A, Aurora-B, and Aurora-C. Among these, Aurora-A and Aurora-B play central roles in mitosis, whereas Aurora-C executes unique roles in meiosis. Overexpression or gene amplification of Aurora kinases has been reported in a broad range of human malignancies, pointing to their role as potent oncogenes in tumorigenesis. Aurora kinases therefore represent promising targets for anticancer therapeutics. A number of Aurora kinase inhibitors (AKIs) have been generated; some of which are currently undergoing clinical evaluation. Recent studies have unveiled novel unexpected functions of Aurora kinases during cancer development and the mechanisms underlying the anticancer actions of AKIs. In this review, we discuss the most recent advances in Aurora-A kinase research and targeted cancer therapy, focusing on the oncogenic roles and signaling pathways of Aurora-A kinases in promoting tumorigenesis, the recent preclinical and clinical AKI data, and potential alternative routes for Aurora-A kinase inhibition.
Issue Date: 13-Jul-2016
Date of Acceptance: 8-Jun-2016
URI: http://hdl.handle.net/10044/1/39196
DOI: https://dx.doi.org/10.1002/med.21399
ISSN: 1098-1128
Publisher: Wiley
Start Page: 1036
End Page: 1079
Journal / Book Title: Medicinal Research Reviews
Volume: 36
Issue: 6
Copyright Statement: This is the peer reviewed version of the following article:Yan, M., Wang, C., He, B., Yang, M., Tong, M., Long, Z., Liu, B., Peng, F., Xu, L., Zhang, Y., Liang, D., Lei, H., Subrata, S., Kelley, K. W., Lam, E. W.-F., Jin, B. and Liu, Q. (2016), Aurora-A Kinase: A Potent Oncogene and Target for Cancer Therapy. Med. Res. Rev., which has been published in final form at https://dx.doi.org/10.1002/med.21399. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
Sponsor/Funder: Imperial College Trust
Funder's Grant Number: N/A
Keywords: Aurora kinase inhibitors (AKIs)
Aurora-A
mitosis
targeted cancer therapy
tumorigenesis
Medicinal & Biomolecular Chemistry
0304 Medicinal And Biomolecular Chemistry
1115 Pharmacology And Pharmaceutical Sciences
Publication Status: Published
Appears in Collections:Division of Surgery
Division of Cancer
Faculty of Medicine



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