Sirtuin1 (SIRT1) in the Acetylation of Downstream Target Proteins.

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Title: Sirtuin1 (SIRT1) in the Acetylation of Downstream Target Proteins.
Authors: Gomes, AR
Yong, JS
Kiew, KC
Aydin, E
Khongkow, M
Laohasinnarong, S
Lam, EW
Item Type: Journal Article
Abstract: Acetylation has been shown to be an important posttranslational modification (PTM) of both histone and nonhistone proteins with particular implications in cell signaling and transcriptional regulation of gene expression. Many studies have already demonstrated that SIRT1 is able to deacetylate histones and lead to gene silencing. It can also regulate the function of tumor suppressors including FOXO proteins and p53 by deacetylation. Here, we describe three experimental approaches for studying the modulation of the acetylation status of some of the known downstream targets of SIRT1.
Issue Date: 1-Jan-2016
Date of Acceptance: 1-Jan-2016
ISSN: 1940-6029
Publisher: Springer
Start Page: 169
End Page: 188
Journal / Book Title: Methods in Molecular Biology
Volume: 1436
Copyright Statement: The final publication is available at Springer via
Sponsor/Funder: Cancer Research UK
Breast Cancer Campaign and Breakthrough Breast Cancer
Funder's Grant Number: C37/A12011
Keywords: Acetylation
Site-directed mutagenesis
Western blotting
Developmental Biology
0601 Biochemistry And Cell Biology
Publication Status: Published
Appears in Collections:Division of Surgery
Division of Cancer
Faculty of Medicine

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