Role and regulation of the forkhead transcription factors FOXO3a and FOXM1 in carcinogenesis and drug resistance

Title: Role and regulation of the forkhead transcription factors FOXO3a and FOXM1 in carcinogenesis and drug resistance
Author(s): Gomes, AR
Zhao, F
Lam, EW
Item Type: Journal Article
Abstract: The FOXO3a and FOXM1 forkhead transcription factors are key players in cancer initiation, progression, and drug resistance. Recent research shows that FOXM1 is a direct transcriptional target of FOXO3a, a vital downstream effector of the PI3K-AKT-FOXO signaling cascade. In addition, FOXM1 and FOXO3a also antagonize each other's activity by competitively binding to the same target genes, which are involved in chemotherapeutic drug sensitivity and resistance. Understanding the role and regulation of the FOXO-FOXM1 axis will provide insight into chemotherapeutic drug action and resistance in patients, and help to identify novel therapeutic approaches as well as diagnostic and predictive biomarkers.
Publication Date: 31-Aug-2016
Date of Acceptance: 18-Feb-2013
URI: http://hdl.handle.net/10044/1/39192
DOI: http://dx.doi.org/10.5732/cjc.012.10277
ISSN: 1944-446X
Publisher: BioMed Central
Start Page: 365
End Page: 370
Journal / Book Title: Chinese Journal of Cancer
Volume: 32
Issue: 7
Copyright Statement: © Chinese Journal of Cancer 2013
Keywords: Antineoplastic Agents
Carcinogenesis
Drug Resistance, Neoplasm
Forkhead Transcription Factors
Humans
Neoplasms
Phosphatidylinositol 3-Kinases
Proto-Oncogene Proteins c-akt
Signal Transduction
Humans
Neoplasms
Antineoplastic Agents
Signal Transduction
Drug Resistance, Neoplasm
Proto-Oncogene Proteins c-akt
Forkhead Transcription Factors
Phosphatidylinositol 3-Kinases
Carcinogenesis
Oncology & Carcinogenesis
1112 Oncology And Carcinogenesis
Publication Status: Published
Appears in Collections:Division of Surgery
Division of Cancer
Faculty of Medicine



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