Promiscuous and lineage-specific roles of cell cycle regulators in haematopoiesis

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Title: Promiscuous and lineage-specific roles of cell cycle regulators in haematopoiesis
Authors: Myatt, SS
Lam, EW
Item Type: Journal Article
Abstract: Haematopoietic cell number is maintained by a delicate balance between cell proliferation, differentiation and death. Gene knockout studies in mice have revealed the complex roles of cyclins, CDKs, and CDK inhibitors in regulating cell proliferation and differentiation in the haematopoietic system. These studies point to families of cell cycle regulators which display both redundant and unique roles within a lineage and developmental-stage specific manner. Moreover, the promiscuity of these cell cycle regulators is critical for haematopoietic cell proliferation and differentiation. In this review, we discuss the current evidence from mouse models that the complexity and multifarious nature of the haematopoietic system is critical for its form and function.
Issue Date: 12-Feb-2007
Date of Acceptance: 12-Feb-2007
URI: http://hdl.handle.net/10044/1/39181
DOI: http://dx.doi.org/10.1186/1747-1028-2-6
ISSN: 1747-1028
Publisher: BioMed Central
Journal / Book Title: Cell Division
Volume: 2
Copyright Statement: © Myatt and Lam. 2007. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Developmental Biology
1199 Other Medical And Health Sciences
Publication Status: Published
Article Number: 6
Appears in Collections:Division of Surgery
Division of Cancer
Faculty of Medicine



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