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Early-life nutrition modulates the epigenetic state of specific rDNA genetic variants in mice

Title: Early-life nutrition modulates the epigenetic state of specific rDNA genetic variants in mice
Authors: Holland, ML
Lowe, R
Caton, PW
Gemma, C
Carbajosa, G
Danson, AF
Carpenter, AA
Loche, E
Ozanne, SE
Rakyan, VK
Item Type: Journal Article
Abstract: A suboptimal early-life environment, due to poor nutrition or stress during pregnancy, can influence lifelong phenotypes in the progeny. Epigenetic factors are thought to be key mediators of these effects. We show that protein restriction in mice from conception until weaning induces a linear correlation between growth restriction and DNA methylation at ribosomal DNA (rDNA). This epigenetic response remains into adulthood and is restricted to rDNA copies associated with a specific genetic variant within the promoter. Related effects are also found in models of maternal high-fat or obesogenic diets. Our work identifies environmentally induced epigenetic dynamics that are dependent on underlying genetic variation and establishes rDNA as a genomic target of nutritional insults.
Issue Date: 29-Jul-2016
Date of Acceptance: 28-Jun-2016
URI: http://hdl.handle.net/10044/1/38921
DOI: http://dx.doi.org/10.1126/science.aaf7040
ISSN: 1095-9203
Publisher: American Association for the Advancement of Science
Journal / Book Title: Science
Volume: 353
Issue: 6298
Keywords: General Science & Technology
MD Multidisciplinary
Publication Status: Published
Open Access location: https://www.repository.cam.ac.uk/handle/1810/256987
Appears in Collections:Division of Cancer



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