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Tailoring mechanical properties of sol-gel hybrids for bone regeneration through polymer structure

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Title: Tailoring mechanical properties of sol-gel hybrids for bone regeneration through polymer structure
Authors: Chung, J
Li, S
Stevens, MM
Georgiou, T
Jones, JR
Item Type: Journal Article
Abstract: Bioglass® was the first synthetic biomaterial that formed a chemical bond to bone. Although bioactive glass scaffolds can mimic bone’s porous structure, they are brittle. Sol-gel derived hybrids could overcome this problem because their nanoscale co-networks of silica and organic polymer have the potential to provide unique physical properties and controlled homogenous biodegradation. Copolymers of methyl methacrylate (MMA) and 3-(trimethoxysilyl)propyl methacrylate (TMSPMA) has been used as an organic source for hybrids to take advantage of its self-hardening property. However, the effect of well-defined poly(MMA-co-TMSPMA) architecture in the hybrid system has not been investigated. Here, linear, randomly branched and star shaped methacrylate based copolymers were synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization method. These copolymers were then used to fabricate hybrids. The 3-D polymer structure had a significant effect on mechanical properties, providing higher strain to failure while maintaining a compressive strength similar to sol-gel glass. Star copolymer-SiO2 hybrids had a modulus of toughness 9.6 fold greater, and Young’s modulus 4.5 fold lower than a sol-gel derived bioactive glass. During in vitro cell culture, MC3T3-E1 osteoblast precursor cells adhered on the surface regardless of the polymer structure. Introducing star polymers to inorganic-organic hybrids opens up possibilities for the fine-tuning physical properties of bone scaffold materials
Issue Date: 1-Aug-2016
Date of Acceptance: 1-Aug-2016
URI: http://hdl.handle.net/10044/1/38822
DOI: https://dx.doi.org/10.1021/acs.chemmater.6b01941
ISSN: 1520-5002
Publisher: American Chemical Society
Start Page: 6127
End Page: 6135
Journal / Book Title: Chemistry of Materials
Volume: 28
Issue: 17
Copyright Statement: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Chemistry of Materials, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://dx.doi.org/10.1021/acs.chemmater.6b01941
Sponsor/Funder: Engineering & Physical Science Research Council (EPSRC)
Funder's Grant Number: EP/M019950/1
Keywords: Materials
03 Chemical Sciences
09 Engineering
Publication Status: Published
Appears in Collections:Faculty of Engineering
Materials
Faculty of Natural Sciences



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