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Crossing the threshold: can outcome data from food challenges be used to predict risk of anaphylaxis in the community?

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Title: Crossing the threshold: can outcome data from food challenges be used to predict risk of anaphylaxis in the community?
Authors: Turner, PJ
Wainstein, BK
Item Type: Journal Article
Abstract: There is increasing interest in using data from oral food challenges (OFC) performed under medical supervision to assist in allergy risk management, both in industry (allergen risk management) (1) and in the clinical management of the allergic individual (2). Data relating to the minimum eliciting dose (MED) needed to trigger symptoms can inform the need for precautionary allergen labelling (PAL) on food (1). However, given that “zero risk” for food-allergic individuals is not considered to be a realistic proposition (3), it is also important to consider the severity of symptoms which might be experienced: for example, a pragmatic approach, using a level of exposure that causes only minimal, transient oral symptoms in under 1% of the food-allergic population, may be acceptable to guide the use of PAL (4). However, there is often an assumption that individuals with a lower MED (i.e. who react to a lower doses of allergen) are at a greater risk of anaphylaxis (5).
Issue Date: 13-Dec-2016
Date of Acceptance: 26-Jul-2016
URI: http://hdl.handle.net/10044/1/37547
DOI: https://dx.doi.org/10.1111/all.12997
ISSN: 1398-9995
Publisher: Wiley
Start Page: 9
End Page: 12
Volume: 72
Issue: 1
Copyright Statement: © 2016 The Authors. Allergy Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: Medical Research Council (MRC)
National Institute for Health Research
Funder's Grant Number: MR/K010468/1
RDD02
Keywords: Science & Technology
Life Sciences & Biomedicine
Allergy
Immunology
ALLERGIC REACTIONS
CLINICAL THRESHOLDS
DOUBLE-BLIND
PEANUT
REQUIRES
LEVEL
MILK
IGE
EGG
1107 Immunology
Publication Status: Published
Appears in Collections:Department of Medicine
Faculty of Medicine



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