Epidemiology of severe anaphylaxis: can we use population-based data to understand anaphylaxis?

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Title: Epidemiology of severe anaphylaxis: can we use population-based data to understand anaphylaxis?
Authors: Turner, PJ
Campbell, DE
Item Type: Journal Article
Abstract: Purpose of review: The observed increase in incidence of allergic disease in many regions over the past 3 decades has intensified interest in understanding the epidemiology of severe allergic reactions. We discuss the issues in collecting and interpreting these data, and highlight current deficiencies in the current methods of data gathering. Recent findings: Anaphylaxis, as measured by hospital admission rates, is not uncommon and has increased in the UK, USA, Canada and Australia over the last 10-20 years. All large datasets are hampered by a large proportion of uncoded “unspecified” causes of anaphylaxis. Fatal anaphylaxis remains a rare event, but appears to be increasing for medication in Australia Canada and the USA. The rate of fatal food anaphylaxis is stable in the UK and USA, but has increased in Australia. The age-distribution for fatal food anaphylaxis is different to other causes, with data suggesting an age-related predisposition to fatal outcomes in teenagers and adults to the fourth decade of life. Summary: The increasing rates of food and medication allergy (the latter exacerbated by an ageing population) has significant implications for future fatality trends. An improved ability to accurately gather and analyse population level anaphylaxis data in a harmonised fashion is required, so as to ultimately minimise risk and improve management.
Issue Date: 4-Aug-2016
Date of Acceptance: 15-Jul-2016
ISSN: 1528-4050
Publisher: Lippincott, Williams & Wilkins
Start Page: 441
End Page: 450
Journal / Book Title: Current Opinion in Allergy and Clinical Immunology
Volume: 16
Issue: 5
Copyright Statement: This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0, where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially.
Sponsor/Funder: Medical Research Council (MRC)
National Institute for Health Research
Funder's Grant Number: MR/K010468/1
Keywords: Allergy
1107 Immunology
Publication Status: Published
Appears in Collections:Department of Medicine
Faculty of Medicine

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