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Advances in genetics: widening our understanding of prostate cancer

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Title: Advances in genetics: widening our understanding of prostate cancer
Authors: Pine, AC
Fioretti, FF
Brooke, GN
Bevan, CL
Item Type: Journal Article
Abstract: Prostate cancer is a leading cause of cancer-related death in Western men. Our understanding of the genetic alterations associated with disease predisposition, development, progression, and therapy response is rapidly improving, at least in part, owing to the development of next-generation sequencing technologies. Large advances have been made in our understanding of the genetics of prostate cancer through the application of whole-exome sequencing, and this review summarises recent advances in this field and discusses how exome sequencing could be used clinically to promote personalised medicine for prostate cancer patients.
Issue Date: 27-Jun-2016
Date of Acceptance: 1-Jun-2016
URI: http://hdl.handle.net/10044/1/37078
DOI: http://dx.doi.org/10.12688/f1000research.8019.1
ISSN: 2046-1402
Publisher: F1000Research
Journal / Book Title: F1000 Research
Volume: 5
Copyright Statement: © 2016 Pine AC et al. This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: Cancer Research UK
Prostate Cancer UK
Funder's Grant Number: C37990/A12196
S12-026
Keywords: Androgen
Cancer progression
DNA damage repair
Metastasis
Personalised Medicine
Prostate Cancer
Transcriptome
WES
Whole Exome Sequencing
Publication Status: Published
Article Number: 1512
Appears in Collections:Division of Surgery
Division of Cancer
Faculty of Medicine



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