Data harmonization and federated analysis of population-based studies: the BioSHaRE project

Title: Data harmonization and federated analysis of population-based studies: the BioSHaRE project
Author(s): Doiron, D
Burton, P
Marcon, Y
Gaye, A
Wolffenbuttel, BH
Perola, M
Stolk, RP
Foco, L
Minelli, C
Waldenberger, M
Holle, R
Kvaløy, K
Hillege, HL
Tassé, AM
Ferretti, V
Fortier, I
Item Type: Journal Article
Abstract: BACKGROUND: Individual-level data pooling of large population-based studies across research centres in international research projects faces many hurdles. The BioSHaRE (Biobank Standardisation and Harmonisation for Research Excellence in the European Union) project aims to address these issues by building a collaborative group of investigators and developing tools for data harmonization, database integration and federated data analyses. METHODS: Eight population-based studies in six European countries were recruited to participate in the BioSHaRE project. Through workshops, teleconferences and electronic communications, participating investigators identified a set of 96 variables targeted for harmonization to answer research questions of interest. Using each studys questionnaires, standard operating procedures, and data dictionaries, harmonization potential was assessed. Whenever harmonization was deemed possible, processing algorithms were developed and implemented in an open-source software infrastructure to transform study-specific data into the target (i.e. harmonized) format. Harmonized datasets located on server in each research centres across Europe were interconnected through a federated database system to perform statistical analysis. RESULTS: Retrospective harmonization led to the generation of common format variables for 73% of matches considered (96 targeted variables across 8 studies). Authenticated investigators can now perform complex statistical analyses of harmonized datasets stored on distributed servers without actually sharing individual-level data using the DataSHIELD method. CONCLUSION: New Internet-based networking technologies and database management systems are providing the means to support collaborative, multi-center research in an efficient and secure manner. The results from this pilot project show that, given a strong collaborative relationship between participating studies, it is possible to seamlessly co-analyse internationally harmonized research databases while allowing each study to retain full control over individual-level data. We encourage additional collaborative research networks in epidemiology, public health, and the social sciences to make use of the open source tools presented herein.
Publication Date: 21-Nov-2013
Date of Acceptance: 11-Nov-2013
ISSN: 1742-7622
Publisher: BioMed Central
Journal / Book Title: Emerging Themes in Epidemiology
Volume: 10
Issue: 12
Copyright Statement: © Doiron et al.; licensee BioMed Central Ltd. 2013 This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Epidemiology
Public Health And Health Services
Publication Status: Published
Conference Place: England
Appears in Collections:Infectious Disease Epidemiology
National Heart and Lung Institute
Faculty of Medicine

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