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Age- and sex-related variations in platelet count in Italy: a proposal of reference ranges based on 40987 subjects' data

Title: Age- and sex-related variations in platelet count in Italy: a proposal of reference ranges based on 40987 subjects' data
Authors: Biino, G
Santimone, I
Minelli, C
Sorice, R
Frongia, B
Traglia, M
Ulivi, S
Di Castelnuovo, A
Gögele, M
Nutile, T
Francavilla, M
Sala, C
Pirastu, N
Cerletti, C
Iacoviello, L
Gasparini, P
Toniolo, D
Ciullo, M
Pramstaller, P
Pirastu, M
De Gaetano, G
Balduini, CL
Item Type: Journal Article
Abstract:  BACKGROUND AND OBJECTIVES: Although several studies demonstrated that platelet count is higher in women, decreases with age, and is influenced by genetic background, most clinical laboratories still use the reference interval 150-400×10(9) platelets/L for all subjects. The present study was to identify age- and sex-specific reference intervals for platelet count. METHODS: We analysed electronic records of subjects enrolled in three population-based studies that investigated inhabitants of seven Italian areas including six geographic isolates. After exclusion of patients with malignancies, liver diseases, or inherited thrombocytopenias, which could affect platelet count, reference intervals were estimated from 40,987 subjects with the non parametric method computing the 2.5° and 97.5° percentiles. RESULTS: Platelet count was similar in men and women until the age of 14, but subsequently women had steadily more platelets than men. The number of platelets decreases quickly in childhood, stabilizes in adulthood, and further decreases in oldness. The final result of this phenomenon is that platelet count in old age was reduced by 35% in men and by 25% in women compared with early infancy. Based on these findings, we estimated reference intervals for platelet count ×10(9)/L in children (176-452), adult men (141-362), adult women (156-405), old men (122-350) and, old women (140-379). Moreover, we calculated an extended reference interval that takes into account the differences in platelet count observed in different geographic areas. CONCLUSIONS: The age-, sex-, and origin-related variability of platelet count is very wide, and the patient-adapted reference intervals we propose change the thresholds for diagnosing both thrombocytopenia and thrombocytosis in Italy.
Issue Date: 31-Jan-2013
Date of Acceptance: 10-Dec-2012
URI: http://hdl.handle.net/10044/1/34665
DOI: https://dx.doi.org/10.1371/journal.pone.0054289
ISSN: 1932-6203
Publisher: Public Library of Science
Journal / Book Title: PLOS One
Volume: 8
Issue: 1
Copyright Statement: © 2013 Biino et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Blood Platelets
Child
Child, Preschool
European Continental Ancestry Group
Female
Humans
Infant
Infant, Newborn
Italy
Male
Middle Aged
Platelet Count
Reference Values
Sex Factors
Thrombocytopenia
Thrombocytosis
General Science & Technology
MD Multidisciplinary
Publication Status: Published
Conference Place: United States
Article Number: ART e54289
Appears in Collections:Infectious Disease Epidemiology
National Heart and Lung Institute
Faculty of Medicine



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