Significant reductions in human visual gamma frequency by the gaba reuptake inhibitor tiagabine revealed by robust peak frequency estimation

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Title: Significant reductions in human visual gamma frequency by the gaba reuptake inhibitor tiagabine revealed by robust peak frequency estimation
Authors: Magazzini, L
Muthukumaraswamy, SD
Campbell, AE
Hamandi, K
Lingford-Hughes, A
Myers, JF
Nutt, DJ
Sumner, P
Wilson, SJ
Singh, KD
Item Type: Journal Article
Abstract: The frequency of visual gamma oscillations is determined by both the neuronal excitation-inhibition balance and the time constants of GABAergic processes. The gamma peak frequency has been linked to sensory processing, cognitive function, cortical structure, and may have a genetic contribution. To disentangle the intricate relationship among these factors, accurate and reliable estimates of peak frequency are required. Here, a bootstrapping approach that provides estimates of peak frequency reliability, thereby increasing the robustness of the inferences made on this parameter was developed. The method using both simulated data and real data from two previous pharmacological MEG studies of visual gamma with alcohol and tiagabine was validated. In particular, the study by Muthukumaraswamy et al. [] (Neuropsychopharmacology 38(6):1105-1112), in which GABAergic enhancement by tiagabine had previously demonstrated a null effect on visual gamma oscillations, contrasting with strong evidence from both animal models and very recent human studies was re-evaluated. After improved peak frequency estimation and additional exclusion of unreliably measured data, it was found that the GABA reuptake inhibitor tiagabine did produce, as predicted, a marked decrease in visual gamma oscillation frequency. This result demonstrates the potential impact of objective approaches to data quality control, and provides additional translational evidence for the mechanisms of GABAergic transmission generating gamma oscillations in humans. Hum Brain Mapp, 2016. © 2016 Wiley Periodicals, Inc.
Issue Date: 7-Jun-2016
Date of Acceptance: 27-May-2016
URI: http://hdl.handle.net/10044/1/34628
DOI: https://dx.doi.org/10.1002/hbm.23283
ISSN: 1097-0193
Publisher: Wiley
Start Page: 3882
End Page: 3896
Journal / Book Title: Human Brain Mapping
Volume: 37
Issue: 11
Copyright Statement: © 2016 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: GABA
bootstrapping
gamma oscillations
magnetoencephalography
peak frequency
tiagabine
Experimental Psychology
1109 Neurosciences
1702 Cognitive Science
Publication Status: Published
Appears in Collections:Department of Medicine
Faculty of Medicine



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