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Moderate Physical Activity in Healthy Adults is Associated with Cardiac Remodeling

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Title: Moderate Physical Activity in Healthy Adults is Associated with Cardiac Remodeling
Authors: Dawes, TJW
Corden, B
Cotter, S
De Marvao, A
Walsh, R
Ware, J
Cook, SA
O'Regan, DP
Item Type: Journal Article
Abstract: Background—Cardiac mass and volumes are often elevated in athletes, but it is not known whether moderate physical activity is also associated with cardiac dilatation and hypertrophy in a healthy adult population. Methods and Results—In total, 1096 adults (54% female, median age 39 years) without cardiovascular disease or cardiomyopathy-associated genetic variants underwent cardiac magnetic resonance imaging to determine biventricular volumes and function. Physical activity was assessed using a validated activity questionnaire. The relationship between cardiac parameters and activity was assessed using multiple linear regression adjusting for age, sex, race, and systolic blood pressure. Logistic regression was performed to determine the effect of activity on the likelihood of subjects having cardiac dilatation or hypertrophy according to standard cardiac magnetic resonance normal ranges. Increasing physical activity was associated with greater left ventricular (LV) mass (β=0.23; P<0.0001) and elevated LV and right ventricular volumes (LV: β=0.26, P<0.0001; right ventricular: β=0.26, P<0.0001). Physical activity had a larger effect on cardiac parameters than systolic blood pressure (0.06≤β≤0.21) and a similar effect to age (−0.20≤β≤−0.31). Increasing physical activity was a risk factor for meeting imaging criteria for LV hypertrophy (adjusted odds ratio 2.1; P<0.0001), LV dilatation (adjusted odds ratio 2.2; P<0.0001), and right ventricular dilatation (adjusted odds ratio 2.2; P<0.0001). Conclusions—Exercise-related cardiac remodeling is not confined to athletes, and there is a risk of overdiagnosing cardiac dilatation or hypertrophy in a proportion of active, healthy adults.
Issue Date: 8-Aug-2016
Date of Acceptance: 23-Jun-2016
URI: http://hdl.handle.net/10044/1/34614
DOI: http://dx.doi.org/10.1161/CIRCIMAGING.116.005321
ISSN: 1942-0080
Publisher: American Heart Association
Journal / Book Title: Circulation-Cardiovascular Imaging
Volume: 9
Issue: 8
Copyright Statement: © 2016 The Authors. Circulation: Cardiovascular Imaging is published on behalf of the American Heart Association, Inc., by Wolters Kluwer. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Sponsor/Funder: Imperial College Healthcare NHS Trust- BRC Funding
British Heart Foundation
Wellcome Trust
Funder's Grant Number: RD410
PG/12/27/29489
107469/Z/15/Z
Keywords: cardiac magnetic resonance imaging
exercise physiology
left ventricular remodeling
remodeling
right ventricle
Cardiovascular System & Hematology
Clinical Sciences
Publication Status: Published
Open Access location: http://circimaging.ahajournals.org/content/9/8/e004712.full
Article Number: e004712
Appears in Collections:Clinical Sciences
Imaging Sciences
National Heart and Lung Institute
Faculty of Medicine



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