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Flavonoid and lignan intake and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

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Title: Flavonoid and lignan intake and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
Authors: Molina-Montes, E
Sánchez, MJ
Zamora-Ros, R
Bueno-de-Mesquita, HB
Wark, PA
Obon-Santacana, M
Kühn, T
Katzke, V
Travis, RC
Ye, W
Sund, M
Naccarati, A
Mattiello, A
Krogh, V
Martorana, C
Masala, G
Amiano, P
Huerta, JM
Barricarte, A
Quirós, JR
Weiderpass, E
Åsli, LA
Skeie, G
Ericson, U
Sonestedt, E
Peeters, PH
Romieu, I
Scalbert, A
Overvad, K
Clemens, M
Boeing, H
Trichopoulou, A
Peppa, E
Vidalis, P
Khaw, KT
Wareham, N
Olsen, A
Tjønneland, A
Boutroun-Rualt, MC
Clavel-Chapelon, F
Cross, AJ
Lu, Y
Riboli, E
Duell, EJ
Item Type: Journal Article
Abstract: © 2016 The Authors International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICCDespite the potential cancer preventive effects of flavonoids and lignans, their ability to reduce pancreatic cancer risk has not been demonstrated in epidemiological studies. Our aim was to examine the association between dietary intakes of flavonoids and lignans and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 865 exocrine pancreatic cancer cases occurred after 11.3 years of follow-up of 477,309 cohort members. Dietary flavonoid and lignan intake was estimated through validated dietary questionnaires and the US Department of Agriculture (USDA) and Phenol Explorer databases. Hazard ratios (HR) and 95% confidence intervals (CIs) were calculated using age, sex and center-stratified Cox proportional hazards models, adjusted for energy intake, body mass index (BMI), smoking, alcohol and diabetes status. Our results showed that neither overall dietary intake of flavonoids nor of lignans were associated with pancreatic cancer risk (multivariable-adjusted HR for a doubling of intake = 1.03, 95% CI: 0.95–1.11 and 1.02; 95% CI: 0.89–1.17, respectively). Statistically significant associations were also not observed by flavonoid subclasses. An inverse association between intake of flavanones and pancreatic cancer risk was apparent, without reaching statistical significance, in microscopically confirmed cases (HR for a doubling of intake = 0.96, 95% CI: 0.91–1.00). In conclusion, we did not observe an association between intake of flavonoids, flavonoid subclasses or lignans and pancreatic cancer risk in the EPIC cohort.
Issue Date: 10-Jun-2016
Date of Acceptance: 28-Apr-2016
URI: http://hdl.handle.net/10044/1/34326
DOI: http://dx.doi.org/10.1002/ijc.30190
ISSN: 1097-0215
Publisher: Wiley
Start Page: 1480
End Page: 1492
Journal / Book Title: International Journal of Cancer
Volume: 139
Issue: 7
Copyright Statement: © 2016 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: Imperial College Trust
Funder's Grant Number: P47328
Keywords: cohort
diet
flavonoids
lignans
pancreatic cancer
Oncology & Carcinogenesis
1112 Oncology And Carcinogenesis
Publication Status: Published
Open Access location: https://www.repository.cam.ac.uk/handle/1810/255988
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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