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25-hydroxyvitamin D deficiency, exacerbation frequency and human rhinovirus exacerbations in chronic obstructive pulmonary disease

Title: 25-hydroxyvitamin D deficiency, exacerbation frequency and human rhinovirus exacerbations in chronic obstructive pulmonary disease
Author(s): Quint, JK
Donaldson, GC
Wassef, N
Hurst, JR
Thomas, M
Wedzicha, JA
Item Type: Journal Article
Abstract: BACKGROUND: 25-hydroxyvitamin D deficiency is associated with COPD and increased susceptibility to infection in the general population. METHODS: We investigated whether COPD patients deficient in 25-hydroxyvitamin D were more likely to be frequent exacerbators, had reduced outdoor activity and were more susceptible to human rhinovirus (HRV) exacerbations than those with insufficient and normal levels. We also investigated whether the frequency of FokI, BsmI and TaqIα 25-hydroxyvitamin D receptor (VDR) polymorphisms differed between frequent and infrequent exacerbators. RESULTS: There was no difference in 25-hydroxyvitamin D levels between frequent and infrequent exacerbators in the summer; medians 44.1 nmol/L (29.1 - 68.0) and 39.4 nmol/L (22.3 - 59.2) or winter; medians 24.9 nmol/L (14.3 - 43.1) and 27.1 nmol/L (19.9 - 37.6). Patients who spent less time outdoors in the 14 days prior to sampling had lower 25-hydroxyvitamin D levels (p = 0.02). Day length was independently associated with 25-hydroxyvitamin D levels (p = 0.02). There was no difference in 25-hydroxyvitamin D levels between baseline and exacerbation; medians 36.2 nmol/L (IQR 22.4-59.4) and 33.3 nmol/L (23.0-49.7); p = 0.43. HRV positive exacerbations were not associated with lower 25-hydroxyvitamin D levels at exacerbation than exacerbations that did not test positive for HRV; medians 30.0 nmol/L (20.4 - 57.8) and 30.6 nmol/L (19.4 - 48.7). There was no relationship between exacerbation frequency and any VDR polymorphisms (all p > 0.05). CONCLUSIONS: Low 25-hydroxyvitamin D levels in COPD are not associated with frequent exacerbations and do not increase susceptibility to HRV exacerbations. Independent of day length, patients who spend less time outdoors have lower 25-hydroxyvitamin D concentration.
Publication Date: 22-Jun-2012
Date of Acceptance: 22-Jun-2012
URI: http://hdl.handle.net/10044/1/34150
DOI: http://dx.doi.org/10.1186/1471-2466-12-28
ISSN: 1471-2466
Publisher: BioMed Central
Journal / Book Title: BMC Pulmonary Medicine
Volume: 12
Copyright Statement: © Quint et al. 2012. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Acute Disease
Aged
Female
Forced Expiratory Volume
Humans
Middle Aged
Photoperiod
Picornaviridae Infections
Polymorphism, Genetic
Pulmonary Disease, Chronic Obstructive
Receptors, Calcitriol
Rhinovirus
Seasons
Vitamin D
Vitamin D Deficiency
Humans
Rhinovirus
Picornaviridae Infections
Pulmonary Disease, Chronic Obstructive
Vitamin D Deficiency
Acute Disease
Vitamin D
Receptors, Calcitriol
Forced Expiratory Volume
Seasons
Polymorphism, Genetic
Photoperiod
Aged
Middle Aged
Female
Respiratory System
1102 Cardiovascular Medicine And Haematology
Publication Status: Published
Article Number: 28
Appears in Collections:National Heart and Lung Institute
Airway Disease
Faculty of Medicine



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