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Bronchiectasis and the risk of cardiovascular disease: A population based study

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Title: Bronchiectasis and the risk of cardiovascular disease: A population based study
Authors: Navaratnam, V
Millett, E
Hurst, J
Thomas, S
Smeeth, L
Hubbard, R
Brown, J
Quint, JK
Item Type: Journal Article
Abstract: Background There are limited data on the burden of cardiovascular comorbidities in people with bronchiectasis. Our cross-sectional study estimates the burden of pre-existing diagnoses of coronary heart disease (CHD) and stroke in people with bronchiectasis compared with the general population. The historical cohort study investigates if individuals with bronchiectasis are at increased risk of incident CHD and stroke events. Methods We used primary care electronic records from the Clinical Practice Research Datalink. The cross-sectional study used logistic regression to quantify the association between bronchiectasis and recorded diagnoses of CHD or stroke. Cox regression was used to investigate if people with bronchiectasis experienced increased incident CHD and strokes compared with the general population, adjusting for age, sex, smoking habit and other risk factors for cardiovascular disease. Results Pre-existing diagnoses of CHD (OR 1.33, 95% CI 1.25 to 1.41) and stroke (OR 1.92, 95% CI 1.85 to 2.01) were higher in people with bronchiectasis compared with those without bronchiectasis, after adjusting for age, sex, smoking and risk factors for cardiovascular disease. The rate of first CHD and stroke were also higher in people with bronchiectasis (HR for CHD 1.44 (95% CI 1.27 to 1.63) and HR for stroke 1.71 (95% CI 1.54 to 1.90)). Conclusion The risk of CHD and stroke are higher among people with bronchiectasis compared with the general population. An increased awareness of these cardiovascular comorbidities in this population is needed to provide a more integrated approach to the care of these patients.
Issue Date: 29-Aug-2016
Date of Acceptance: 27-Jun-2016
URI: http://hdl.handle.net/10044/1/34086
DOI: https://dx.doi.org/10.1136/thoraxjnl-2015-208188
ISSN: 1468-3296
Publisher: BMJ Publishing Group
Start Page: 161
End Page: 166
Journal / Book Title: Thorax
Volume: 72
Copyright Statement: © 2017 The Authors. This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/ by/4.0/
Sponsor/Funder: GlaxoSmithKline Services Unlimited
Funder's Grant Number: PO #3000793769
Keywords: Science & Technology
Life Sciences & Biomedicine
Respiratory System
PRACTICE RESEARCH DATABASE
CORONARY-HEART-DISEASE
RESEARCH DATALINK CPRD
MYOCARDIAL-INFARCTION
STROKE
INFLAMMATION
VALIDATION
COMORBIDITIES
PREVALENCE
MORTALITY
Bronchiectasis
Clinical Epidemiology
Adult
Aged
Cardiovascular Diseases
Cross-Sectional Studies
Female
Humans
Incidence
Male
Middle Aged
Prevalence
Risk Factors
Stroke
United Kingdom
1103 Clinical Sciences
Publication Status: Published
Appears in Collections:National Heart and Lung Institute
Faculty of Medicine



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